Theophylline attenuates hippocampal blood flow responses induced by tooth pulp stimulation in rats

被引：4

作者：

Hasegawa, Makoto ^{[1
]}

Hada, Junichi ^{[2
]}

Abe, Tetsuya ^{[1
]}

Honda, Kousuke ^{[1
]}

Shimizu, Akihiko ^{[1
]}

Urade, Masahiro ^{[1
]}

机构：

[1] Hyogo Coll Med, Dept Dent & Oral Surg, Nishinomiya, Hyogo 6638501, Japan

[2] Hyogo Coll Med, Dept Med Phys & Chem, Nishinomiya, Hyogo 6638501, Japan

来源：

NEUROSCIENCE RESEARCH | 2009年 / 65卷 / 02期

关键词：

Adenosine; Hippocampal blood flow; Theophylline; Tooth pulp stimulation; NMDA RECEPTORS; FUNCTIONAL HYPEREMIA; A(2B) RECEPTORS; DENTATE GYRUS; NITRIC-OXIDE; ADENOSINE; ACTIVATION; RELEASE; BRAIN; DILATION;

D O I：

10.1016/j.neures.2009.06.009

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In this study, we performed tests to determine whether tooth pulp stimulation (TPS) increases hippocampal blood flow (HBF), and if so, to investigate whether the increase in HBF is mediated via the activation of adenosine receptors. We measured HBF in urethane-anesthetized rats using laser Doppler flowmetry (LDF) and examined the effect of theophylline, a nonselective adenosine receptor antagonist, on TPS-induced HBF responses. TPS increased HBF, and its response was significantly attenuated by the intraperitoneal administration of theophylline (20 mg/kg). These results suggest that the HBF response induced by TPS may be, at least in part, produced through adenosine receptors. (C) 2009 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

引用

页码：156 / 159

页数：4

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