Transcriptional and epigenetic regulation of memory NK cell responses*

被引:18
作者
Beaulieu, Aimee M. [1 ,2 ]
机构
[1] Rutgers State Univ, Rutgers Biomed & Hlth Sci, New Jersey Med Sch, Ctr Immun & Inflammat, Newark, NJ USA
[2] Rutgers State Univ, Rutgers Biomed & Hlth Sci, New Jersey Med Sch, Dept Microbiol Biochem & Mol Genet, Newark, NJ USA
关键词
epigenetic; memory; natural killer; NK cell; transcription factors;
D O I
10.1111/imr.12947
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Natural killer (NK) cells are cytotoxic innate lymphocytes with key roles in host protection against viruses and malignancy. Notwithstanding their historical classification as innate immune cells, NK cells are now understood to have some capacity to mount memory or memory-like immune responses in which effector cells undergo antigen-driven expansion and give rise to long-lived memory cells with enhanced functionality. Understanding how antigen-specific effector and memory NK responses are regulated is an important and active area of research in the field. Here, we discuss key transcription factors and epigenetic processes involved in antigen-specific effector and memory NK cell differentiation.
引用
收藏
页码:125 / 133
页数:9
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