Pathophysiology of Behcet's disease

被引：17
作者：
Amoura, Z.
Guillaume, M.
Caillat-Zucman, S.
Wechsler, B.
Piette, J. -C.
机构：
[1] Hop La Pitie Salpetriere, Serv Med Interne, Ctr Natl Reference Malad Rares, F-75013 Paris, France
[2] Hop St Vincent de Paul, INSERM, U561, Equipe Avenir, F-75674 Paris, France
来源：
REVUE DE MEDECINE INTERNE | 2006年 / 27卷 / 11期
关键词：
Behcet's disease; pathophysiology;
D O I：
10.1016/j.revmed.2006.02.014
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Subject. - Pathophysiology of Behcet's disease (BD) is complex. Recent experimental data shed new light on the mechanisms leading to organ lesions. Main issues. - Neutrophils and cytotoxic lymphocytes are now recognized as key effector cells in BD. Genetic susceptibility, environmental factors (virus and/or bacterial infections), inflammatory response abnormalities (heat shock proteins, dysregulated NO production) and abnormal immune response play also a major role in BD pathogeny. Perspectives. - Better understanding of the BD pathophysiology will allow the development of new therapies more specific of BD. (C) 2006 Elsevier Masson SAS. Tons droits reserves.
引用
收藏
页码：843 / 853
页数：11
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