Synthesis of new xanthone analogues and their biological activity test - Cytotoxicity, topoisomerase II inhibition, and DNA cross-linking study

被引：84

作者：

Woo, Sangwook

Jung, Ji

Lee, Chongsoon

Kwon, Youngjoo ^{[1
]}

Na, Younghwa

机构：

[1] Ewha Womans Univ, Coll Pharm, Seoul 120750, South Korea

[2] Catholic Univ Daegu, Coll Pharm, Gyongsan 712702, Gyeongbuk, South Korea

[3] Yeungnam Univ, Coll Nat Sci, Dept Biochem, Kyongsan 712749, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 05期

关键词：

xanthones; topoisomerase II inhibition; DNA cross-linking; anti-cancer agents;

D O I：

10.1016/j.bmcl.2006.12.030

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In this report, we prepared some 3-(2',3'-epoxypropoxy)xanthones and their epoxide ring opened halohydrin analogues, and evaluated their cytotoxicity and topoisomerase II inhibition activity using doxorubicin and etoposide as references, respectively. Another xanthone compound 9, 1,3-di(2,3'-epoxypropoxy)xanthone, was also synthesized and its DNA cross-linking property including other two biological activities investigated. The biological test results showed compound 9 possessed excellent cytotoxic and topoisomerase II inhibitory activity than other compounds tested. It also exhibited significant DNA cross-linking activities. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：1163 / 1166

页数：4

共 14 条

[1] XANTHONES .4. A NEW SYNTHESIS OF HYDROXYXANTHONES AND HYDROXYBENZOPHENONES [J].