Objective. The characteristics of the new anti-epileptic drug topiramato (TPM) are described. multiple mechanism of action, favorable pharmaco-kinetics wide therapeutic range and is relatively well tolerated. Development. Its initial usefulness in patients with partial cl ises resistant to other anti-epileptic drugs has been shown. TPM is equally effective ir? primary generalized cr-ises, and in patients with the Lennox-Gastaut syndrome, in whom no problem of tolerance has been seen. Conclusion. TPM is a valuable drug for the treatment of epilepsy [REV NEUROL 1997; 25: 1221-5].
机构:
Univ Iowa Hosp & Clin, Dept Pathol, Iowa City, IA 52242 USAUniv Iowa Hosp & Clin, Dept Pathol, Iowa City, IA 52242 USA
Krasowski, Matthew D.
McMillin, Gwendolyn A.
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机构:
Univ Utah, Sch Med, Dept Pathol, Salt Lake City, UT USA
ARUP Labs Inc, ARUP Inst Clin & Expt Pathol, Salt Lake City, UT USAUniv Iowa Hosp & Clin, Dept Pathol, Iowa City, IA 52242 USA