Cerebrospinal fluid bactericidal activity against cephalosporin-resistant Streptococcus pneumoniae in children with meningitis treated with high-dosage cefotaxime

被引：29

作者：

Friedland, IR

Klugman, KP

机构：

[1] BARAGWANATH HOSP,DEPT PEDIAT,ZA-2013 JOHANNESBURG,SOUTH AFRICA

[2] UNIV WITWATERSRAND,JOHANNESBURG,SOUTH AFRICA

[3] MRC,PNEUMOCOCCAL DIS RES UNIT,JOHANNESBURG,SOUTH AFRICA

[4] SOUTH AFRICAN INST MED RES,JOHANNESBURG,SOUTH AFRICA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1997年 / 41卷 / 09期

关键词：

D O I：

10.1128/AAC.41.9.1888

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We determined cefotaxime and desacetyl-cefotaxime concentrations in children with bacterial meningitis receiving high-dose cefotaxime (300 mg/kg of body weight/day) and concomitant dexamethasone therapy, The median peak cerebrospinal fluid cefotaxime and desacetyl-cefotaxime concentrations were 4.7 and 8.1 mu g/ml, respectively, In vitro bactericidal activity (>99.9% killing in 6 h) was found in 17 (94%), 13 (72%), and 8 (44%) of 18 cerebrospinal fluid specimens against cefotaxime-susceptible, -intermediate (MIC, 1 mu g/ml), and -resistant (MIC, 4 mu g/ml) strains, respectively, High-dose cefotaxime, while safe, is not reliably sufficient therapy for cephalosporin-nonsusceptible pneumococcal meningitis, and combination therapy is recommended.

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页码：1888 / 1891

页数：4

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