Indium-Catalyzed Aromative Spiro Coupling of Quinones with Oxindoles for Highly Functionalized Xanthenes as Efficient Fluorophores

被引：11

作者：

Aslam, Mohammad ^{[1
]}

Mohandoss, Sonaimuthu ^{[1
]}

Subramanian, Palanisamy ^{[2
]}

You, SangGuan ^{[2
]}

Yang, Won-Guen ^{[3
]}

Kim, Sung Hong ^{[3
]}

Lee, Yong Rok ^{[1
]}

机构：

[1] Yeungnam Univ, Sch Chem Engn, Gyongsan 38541, South Korea

[2] Gangneung Wonju Natl Univ, Dept Marine Food Sci & Technol, Kangnung 25457, Gangwon, South Korea

[3] Korea Basic Sci Inst, Daegu Ctr, Anal Res Div, Daegu 41566, South Korea

来源：

ORGANIC LETTERS | 2021年 / 23卷 / 04期

基金：

新加坡国家研究基金会;

关键词：

D O I：

10.1021/acs.orglett.1c00042

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient and an efficient protocol for the assembly of diverse xanthenes bearing a biologically interesting oxindole nucleus is developed by utilizing the In(III)-catalyzed spiro coupling of 1,4-benzoquinones or 1,4-naphthoquinones with oxindoles. This novel protocol proceeds via a cascade of double Michael additions and intramolecular cyclization. The synthesized compounds have potential use as fluorophores for the selective imaging of heavy metals in living cells.

引用

页码：1383 / 1387

页数：5

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