The Pro12Ala polymorphism in PPAR γ2 may confer resistance to type 2 diabetes

被引：252

作者：

Hara, K

Okada, T

Tobe, K

Yasuda, K

Mori, Y

Kadowaki, H

Hagura, R

Akanuma, Y

Kimura, S

Ito, C

Kadowaki, T

机构：

[1] Univ Tokyo, Grad Sch Med, Dept Metab Dis, Bunkyo Ku, Tokyo 1138655, Japan

[2] Asahi Life Fdn, Inst Diabet Care & Res, Tokyo, Japan

[3] Chiba Univ, Sch Med, Dept Med Genet, Chiba 280, Japan

[4] Hiroshima Atom Bomb Casualty Council, Hlth Management Ctr, Hiroshima, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2000年 / 271卷 / 01期

关键词：

peroxisome proliferator-activated receptor gamma; Pro12Ala polymorphism; insulin resistance; type; 2; diabetes; thrifty gene;

D O I：

10.1006/bbrc.2000.2605

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Peroxisome proliferator-activated receptor gamma (PPAR gamma) has been implicated in adipocyte differentiation. Recently it was reported that heterozygous deficiency of PPAR gamma led to the protection from high-fat diet-induced insulin resistance in an animal model. A Pro12Ala polymorphism has been detected in the human PPAR gamma 2 gene. Since this amino acid substitution may cause a reduction in the transcriptional activity of PPAR gamma, this polymorphism may be associated with decreased insulin resistance and decreased risk of type 2 diabetes. To investigate this hypothesis, we performed a case-control study of the Pro12Ala PPAR gamma 2 polymorphism in Japanese diabetic and non-diabetic subjects. The frequency of Ala12 was significantly lower in the diabetic group. In an overweight or obese group, subjects with Ala12 were more insulin sensitive than those without. These results suggest that the PPAR gamma is a thrifty gene and that the Pro12Ala PPAR gamma 2 polymorphism protects against type 2 diabetes in the Japanese. (C) 2000 Academic Press. Press.

引用

页码：212 / 216

页数：5

共 17 条

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