Transition-metal-free cascade reaction of α-halo-N-tosylhydrazones, indoles and arylboronic acids

被引：21
|
作者：
Wu, Guojiao [1 ]
Deng, Yifan [1 ]
Luo, Haiqing [1 ]
Zhou, Junliang [1 ]
Li, Tianjiao [1 ]
Zhang, Yan [1 ]
Wang, Jianbo [1 ,2 ]
机构：
[1] Peking Univ, Key Lab Bioorgan Chem & Mol Engn, Coll Chem, Minist Educ,BNLMS, Beijing 100871, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 30期
关键词：
SITU GENERATED 1,2-DIAZA-1,3-DIENES; IN-SITU; EFFICIENT SYNTHESIS; CARBONYL-COMPOUNDS; COUPLING REACTIONS; BORONIC ACIDS; AZOALKENES; CARBENE; CYCLOADDITION; INSERTION;
D O I：
10.1039/c6cc01750a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
alpha-Halo-N-tosylhydrazones are employed as reagents for the formation of multiple carbon-carbon bonds in the three-component reactions. In this transformation, a strategy has been designed to generate the diazo intermediate by using a nucleophile to react with the azoalkene intermediate generated in situ from the alpha-halo-N-tosylhydrazone. The diazo intermediate thus generated further undergoes transition-metal-free C-C bond forming reaction with arylboronic acids.
引用
收藏
页码：5266 / 5268
页数：3
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