Multitarget therapy - The future of treatment for more than just functional dyspepsia

被引：82

作者：

Wagner, H. ^{[1
]}

机构：

[1] Univ Munich, Dept Pharm, Ctr Pharmares, D-81377 Munich, Germany

来源：

PHYTOMEDICINE | 2006年 / 13卷

关键词：

multitarget therapy; synergy effects; molecular pharmacology; clinical evidences;

D O I：

10.1016/j.phymed.2006.03.021

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Since many years the concept of classical phytotherapy using herbal drug combinations with superior efficacy and lesser side effects in comparison with single isolated constituents of plant extracts has been repeatedly assessed clinically as well as pharmacologically. For this as multitarget therapy defined treatment lot of examples are presented. The exact mechanisms of action underlying these synergy effects is unknown. It could be explained by a multitarget action of compounds on a molecular level or partly by an improved resorption rate and a change of pharmacokinetic. Progress in the field of drug synergy research may lend with standardized plant extracts a new legitimacy and may open the chance to use extract combinations for the treatment of diseases which previously have been reserved for chemo therapeutics only. (c) 2006 Elsevier GmbH. All rights reserved.

引用

页码：122 / 129

页数：8

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