Heterocycles as classical and nonclassical ring B isosters in combretastatin A-4

被引：8
作者：
Zefirov, Nikolay A. [1 ]
Zefirova, Olga N. [1 ,2 ]
机构：
[1] Lomonosov Moscow State Univ, Dept Chem, Leninskie Gory 1-3, Moscow 119991, Russia
[2] Inst Physiol Act Cpds, Severny Proezd 1, Chernogolovka 142432, Moscow Region, Russia
来源：
CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2017年 / 53卷 / 03期
基金：
俄罗斯基础研究基金会;
关键词：
combretastatin A-4; cytotoxicity; heterocycles; isosteric replacement; structure-activity relationship; TUBULIN POLYMERIZATION INHIBITORS; COLCHICINE BINDING-SITE; BIOLOGICAL EVALUATION; ANTICANCER AGENTS; COMMON PHARMACOPHORE; CYTOTOXIC ACTIVITIES; ANTIMITOTIC AGENTS; DRUG DESIGN; ANALOGS; DERIVATIVES;
D O I：
10.1007/s10593-017-2049-1
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The minireview provides a survey of combretastatin A-4 analogs, obtained by isosteric replacement of 3-hydroxy-4-methoxyphenyl ring (ring B) with various heterocyclic systems. The basic synthetic approaches and structure-activity relationships are summarized.
引用
收藏
页码：273 / 280
页数：8
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