The Role of Mitochondria in the Chemoresistance of Pancreatic Cancer Cells

被引：33

作者：

Fu, Yibo ^{[1
]}

Ricciardiello, Francesca ^{[2
]}

Yang, Gang ^{[1
]}

Qiu, Jiangdong ^{[1
]}

Huang, Hua ^{[1
]}

Xiao, Jianchun ^{[1
]}

Cao, Zhe ^{[1
]}

Zhao, Fangyu ^{[1
]}

Liu, Yueze ^{[1
]}

Luo, Wenhao ^{[1
]}

Chen, Guangyu ^{[1
]}

You, Lei ^{[1
]}

Chiaradonna, Ferdinando ^{[2
]}

Zheng, Lianfang ^{[3
]}

Zhang, Taiping ^{[1
,4
]}

机构：

[1] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, State Key Lab Complex Severe & Rare Dis, Gen Surg Dept, Beijing 100730, Peoples R China

[2] Univ Milano Bicocca, Dept Biotechnol & Biosci, I-20126 Milan, Italy

[3] Chinese Acad Med Sci & Peking Union Med Coll, Dept Nucl Med, Peking Union Med Coll Hosp, Beijing 100730, Peoples R China

[4] Chinese Acad Med Sci & Peking Union Med Coll, Clin Immunol Ctr, Beijing 100730, Peoples R China

来源：

CELLS | 2021年 / 10卷 / 03期

基金：

中国国家自然科学基金;

关键词：

pancreatic cancer; mitochondria; chemoresistance; metabolism; apoptosis; K-RAS MUTATIONS; ANABOLIC GLUCOSE-METABOLISM; GLUTAMINE-METABOLISM; DNA MUTATIONS; ACINAR-CELLS; OXIDATIVE STRESS; DRUG-RESISTANCE; MUTANT KRAS; DUCTAL ADENOCARCINORNA; GEMCITABINE RESISTANCE;

D O I：

10.3390/cells10030497

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The first-line chemotherapies for patients with unresectable pancreatic cancer (PC) are 5-fluorouracil (5-FU) and gemcitabine therapy. However, due to chemoresistance the prognosis of patients with PC has not been significantly improved. Mitochondria are essential organelles in eukaryotes that evolved from aerobic bacteria. In recent years, many studies have shown that mitochondria play important roles in tumorigenesis and may act as chemotherapeutic targets in PC. In addition, according to recent studies, mitochondria may play important roles in the chemoresistance of PC by affecting apoptosis, metabolism, mtDNA metabolism, and mitochondrial dynamics. Interfering with some of these factors in mitochondria may improve the sensitivity of PC cells to chemotherapeutic agents, such as gemcitabine, making mitochondria promising targets for overcoming chemoresistance in PC.

引用

页码：1 / 33

页数：31

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