The Role of Hypoxia-Inducible Factor Post-Translational Modifications in Regulating Its Localisation, Stability, and Activity

被引：95
作者：
Albanese, Adam [1 ]
Daly, Leonard A. [2 ]
Mennerich, Daniela [3 ]
Kietzmann, Thomas [3 ]
See, Violaine [1 ]
机构：
[1] Univ Liverpool, Inst Syst Mol & Integrat Biol, Dept Mol Physiol & Cell Signalling, Liverpool L697ZB, Merseyside, England
[2] Univ Liverpool, Inst Syst Mol & Integrat Biol, Dept Biochem & Syst Biol, Liverpool L697ZB, Merseyside, England
[3] Univ Oulu, Fac Biochem & Mol Med, Bioctr Oulu, FI-90014 Oulu, Finland
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 01期
基金：
芬兰科学院; 英国生物技术与生命科学研究理事会;
关键词：
hypoxia; HIF-1; alpha; HIF-2; posttranslational modifications; phosphorylation; cysteine phosphorylation; methylation; acetylation; ubiquitination; sumoylation; S-nitrosylation; signalling; CYCLIN-DEPENDENT KINASES; FACTOR-KAPPA-B; FACTOR-L-ALPHA; FACTOR; 1-ALPHA; TUMOR-SUPPRESSOR; CANCER-CELLS; DIRECT PHOSPHORYLATION; CELLULAR-RESPONSE; CASEIN KINASE-2; HIF-ALPHA;
D O I：
10.3390/ijms22010268
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The hypoxia signalling pathway enables adaptation of cells to decreased oxygen availability. When oxygen becomes limiting, the central transcription factors of the pathway, hypoxia-inducible factors (HIFs), are stabilised and activated to induce the expression of hypoxia-regulated genes, thereby maintaining cellular homeostasis. Whilst hydroxylation has been thoroughly described as the major and canonical modification of the HIF-alpha subunits, regulating both HIF stability and activity, a range of other post-translational modifications decorating the entire protein play also a crucial role in altering HIF localisation, stability, and activity. These modifications, their conservation throughout evolution, and their effects on HIF-dependent signalling are discussed in this review.
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页码：1 / 18
页数：17
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