Substituted galacturonan from starfruit: Chemical structure and antinociceptive and anti-inflammatory effects

被引：18

作者：

Leivas, Carolina L. ^{[1
]}

Nascimento, Leandro F. ^{[2
]}

Barros, Wellinghton M. ^{[2
]}

Santos, Adair R. S. ^{[2
]}

Iacomini, Marcello ^{[1
]}

Cordeiro, Lucimara M. C. ^{[1
]}

机构：

[1] Univ Fed Parana, Dept Bioquim & Biol Mol, CP 19-046, BR-81531980 Curitiba, Parana, Brazil

[2] Univ Fed Santa Catarina, Dept Ciencias Fisiol, BR-88040900 Florianopolis, SC, Brazil

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2016年 / 84卷

关键词：

Starfruit; Substituted galacturonans; Anti-inflammatory and antinociceptive activities; FORMALIN TEST; PECTIC POLYSACCHARIDE; AVERRHOA-CARAMBOLA; RECEPTOR SUBTYPES; ARABINOGALACTAN; MODELS; PAIN; MICE; EXTRACT; FIBERS;

D O I：

10.1016/j.ijbiomac.2015.12.034

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Starfruit (Averrhoa carambola L) is an edible tropical fruit, which is usually consumed as a fresh table fruit or as fruit juice. It also exhibits various pharmacological activities. In this study, polysaccharides were extracted with boiling water and purified by freeze-thawing and Fehling treatments. After purification steps, a homogenous fraction was obtained. It was analyzed by sugar composition, gel permeation chromatography, methylation, and two-dimensional nuclear magnetic resonance (2D NMR) spectroscopy analyses. It comprised arabinose (Ara), galactose (Gal), and galacturonic acid (GalA) in a molar ratio of 12.3:1.7:86.0. Methylation and NMR spectroscopy analyses showed that it contained a substituted galacturonan composed of (1 -> 4)-linked alpha-D-Galp A units branched at O-2 by (1 -> 5)-linked alpha-l-Araf and terminal alpha-l-Araf and alpha-D-Galp A units. The effect of PFSCW (10-300 mg/kg, i.p.) on nocifensive behavior induced by intraplantar injection of formalin in mice was evaluated. The fraction demonstrated antinociceptive and anti-inflammatory properties, suggesting that it may be useful in therapeutic intervention for the management of inflammatory pain. (C) 2015 Published by Elsevier B.V.

引用

页码：295 / 300

页数：6

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