Metabolomics Applied to Diabetes Research Moving From Information to Knowledge

被引:251
作者
Bain, James R.
Stevens, Robert D.
Wenner, Brett R.
Ilkayeva, Olga
Muoio, Deborah M.
Newgard, Christopher B. [1 ]
机构
[1] Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, Sarah W Stedman Nutr & Metab Ctr, Durham, NC 27710 USA
基金
美国国家卫生研究院;
关键词
STIMULATED INSULIN-SECRETION; NMR ISOTOPOMER ANALYSIS; MASS-SPECTROMETRY; MYOCARDIAL-INFARCTION; H-1-NMR METABONOMICS; SHOTGUN LIPIDOMICS; PROFILING REVEALS; CRUDE EXTRACTS; ADIPOSE-TISSUE; WEIGHT-LOSS;
D O I
10.2337/db09-0580
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
[No abstract available]
引用
收藏
页码:2429 / 2443
页数:15
相关论文
共 84 条
  • [1] Bioinformatics analysis of targeted metabolomics - Uncovering old and new tales of diabetic mice under medication
    Altmaier, Elisabeth
    Ramsay, Steven L.
    Graber, Armin
    Mewes, Hans-Werner
    Weinberger, Klaus M.
    Suhre, Karsten
    [J]. ENDOCRINOLOGY, 2008, 149 (07) : 3478 - 3489
  • [2] Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance
    An, J
    Muoio, DM
    Shiota, M
    Fujimoto, Y
    Cline, GW
    Shulman, GI
    Koves, TR
    Stevens, R
    Millington, D
    Newgard, CB
    [J]. NATURE MEDICINE, 2004, 10 (03) : 268 - 274
  • [3] A combined 1H-NMR spectroscopy- and mass spectrometry-based metabolomic study of the PPAR-α null mutant mouse defines profound systemic changes in metabolism linked to the metabolic syndrome
    Atherton, Helen J.
    Bailey, Nigel J.
    Zhang, Wen
    Taylor, John
    Major, Hilary
    Shockcor, John
    Clarke, Kieran
    Griffin, Julian L.
    [J]. PHYSIOLOGICAL GENOMICS, 2006, 27 (02) : 178 - 186
  • [4] Mechanisms underlying the resistance to diet-induced obesity in germ-free mice
    Backhed, Fredrik
    Manchester, Jill K.
    Semenkovich, Clay F.
    Gordon, Jeffrey I.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (03) : 979 - 984
  • [5] Metabonomic Variations in the Drug-Treated Type 2 Diabetes Mellitus Patients and Healthy Volunteers
    Bao, Yuqian
    Zhao, Tie
    Wang, Xiaoyan
    Qiu, Yunping
    Su, Mingming
    Jia, Weiping
    Jia, Wei
    [J]. JOURNAL OF PROTEOME RESEARCH, 2009, 8 (04) : 1623 - 1630
  • [6] Biochemical mechanism of lipid-induced impairment of glucose-stimulated insulin secretion and reversal with a malate analogue
    Boucher, A
    Lu, DH
    Burgess, SC
    Telemaque-Potts, S
    Jensen, MV
    Mulder, H
    Wang, MY
    Unger, RH
    Sherry, AD
    Newgard, CB
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (26) : 27263 - 27271
  • [7] Malonyl coenzymeA decarboxylase regulates lipid and glucose metabolism in human skeletal muscle
    Bouzakri, Karim
    Austin, Reginald
    Rune, Anna
    Lassman, Michael E.
    Garcia-Roves, Pablo M.
    Berger, Joel P.
    Krook, Anna
    Chibalin, Alexander V.
    Zhang, Bei B.
    Zierath, Juleen R.
    [J]. DIABETES, 2008, 57 (06) : 1508 - 1516
  • [8] Brindle JT, 2002, NAT MED, V8, P1439, DOI 10.1038/nm802
  • [9] Overexpression of Carnitine Palmitoyltransferase-1 in Skeletal Muscle Is Sufficient to Enhance Fatty Acid Oxidation and Improve High-Fat Diet-Induced Insulin Resistance
    Bruce, Clinton R.
    Hoy, Andrew J.
    Turner, Nigel
    Watt, Matthew J.
    Allen, Tamara L.
    Carpenter, Kevin
    Cooney, Gregory J.
    Febbraio, Mark A.
    Kraegen, Edward W.
    [J]. DIABETES, 2009, 58 (03) : 550 - 558
  • [10] Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism
    Cao, Haiming
    Gerhold, Kristin
    Mayers, Jared R.
    Wiest, Michelle M.
    Watkins, Steven M.
    Hotamisligil, Goekhan S.
    [J]. CELL, 2008, 134 (06) : 933 - 944