Vitamin D and assisted reproductive treatment outcome: a prospective cohort study

被引：26

作者：

Chu, Justin ^{[1
,2
]}

Gallos, Ioannis ^{[1
,2
,4
]}

Tobias, Aurelio ^{[1
,3
]}

Robinson, Lynne ^{[2
]}

Kirkman-Brown, Jackson ^{[1
,2
]}

Dhillon-Smith, Rima ^{[1
,2
]}

Harb, Hoda ^{[1
,2
]}

Eapen, Abey ^{[1
,2
]}

Rajkhowa, Madhurima ^{[2
]}

Coomarasamy, Arri ^{[1
,2
]}

机构：

[1] Univ Birmingham, Inst Metab & Syst Res, Tommys Natl Ctr Miscarriage Res, Birmingham B15 2TT, W Midlands, England

[2] Birmingham Womens & Childrens Natl Fdn Trust, Mindelsohn Way, Birmingham B15 2TG, W Midlands, England

[3] Spanish Council Sci Res, Inst Environm Assessment & Water Res, Barcelona, Spain

[4] Birmingham Womens Fdn NHS Trust, Edgbaston B15 2TG, England

来源：

REPRODUCTIVE HEALTH | 2019年 / 16卷 / 1期

基金：

美国国家卫生研究院;

关键词：

Vitamin D; Implantation; Assisted reproductive treatment; D DEFICIENCY; FOLLICULAR-FLUID; RISK; FERTILIZATION; PREGNANCY; FEMALE; POLYMORPHISMS; EMBRYO; HEALTH; WOMEN;

D O I：

10.1186/s12978-019-0769-7

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

BackgroundVitamin D deficiency has been associated with an increased risk of abnormal pregnancy implantation leading to obstetric complications such as pre-eclampsia and fetal growth restriction. However, the effect of vitamin D on reproductive treatment outcomes in couples undergoing assisted reproductive treatment is poorly understood. This study investigates the association between vitamin D and reproductive treatment outcomes in women undergoing assisted reproductive treatments?MethodsA prospective cohort study conducted at a large tertiary teaching hospital, United Kingdom. Five hundred women undergoing assisted reproductive treatment were recruited between September 2013 and September 2015. All participants had their serum vitamin D measured and their reproductive treatment outcomes collated. Women were categorised in to three groups: vitamin D replete (>75nmol/L), insufficient (50-75nmol/L) and deficient (<50nmol/L) according to Endocrine Society guidance. The primary outcome was live birth. Secondary outcomes included biochemical pregnancy, clinical pregnancy and pregnancy loss rates.ResultsVitamin D deficiency was found in 53.2% (266/500) of participants and vitamin D insufficiency was found in 30.8% (154/500) of participants. Only 16% (80/500) of women were vitamin D replete. The live birth rates for vitamin D deficient, insufficient and replete women were 23.2% (57/246), 27.0% (38/141) and 37.7% (29/77) respectively (p=0.04). The respective live birth rates for vitamin D deficient, insufficient and replete women were 24.3, 27.1, 34.4% after adjustment for key prognostic factors (p=0.25).ConclusionsVitamin D deficiency and insufficiency are common in women undergoing assisted reproductive treatments. The crude live birth rate achieved in women undergoing assisted reproductive treatments are associated with serum vitamin D, although statistical significance is lost when adjusting for important prognostic variables. Vitamin D deficiency could be an important condition to treat in women considering fertility treatment. A research trial to investigate the benefits of vitamin D deficiency treatment would test this hypothesis.Trial registrationClinicaltrials.gov - NCT02187146.

引用

页数：10

共 34 条

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