Mercury speciation in prenatal exposure in Slovenian and Croatian population - PHIME study

被引:8
作者
Trdin, Ajda [1 ,2 ]
Tratnik, Janja Snoj [1 ,2 ]
Mazej, Darja [1 ]
Fajon, Vesna [1 ,2 ]
Krsnik, Mladen [3 ]
Osredkar, Josko [3 ]
Prpic, Igor [4 ]
Spiric, Zdravko [5 ]
Petrovic, Oleg [6 ]
Marc, Janj A. [7 ]
Neubauer, David [8 ]
Kodric, Jana [8 ]
Kobal, Alfred B. [1 ]
Barbone, Fabio [9 ]
Falnoga, Ingrid [1 ]
Horvat, Milena [1 ,2 ]
机构
[1] Jozef Stefan Inst, Dept Environm Sci, Ljubljana, Slovenia
[2] Jozef Stefan Int Postgrad Sch, Ljubljana, Slovenia
[3] Univ Med Ctr Ljubljana, Inst Clin Chem & Biochem, Ljubljana, Slovenia
[4] Univ Hosp Ctr Rijeka, Dept Paediat, Rijeka, Croatia
[5] Green Infrastruct Ltd, Zagreb, Croatia
[6] Univ Hosp Ctr Rijeka, Dept Obstet & Gynaecol, Rijeka, Croatia
[7] Univ Ljubljana, Fac Pharm, Ljubljana, Slovenia
[8] Univ Med Ctr Ljubljana, Div Paediat, Dept Child Adolescent & Dev Neurol, Ljubljana, Slovenia
[9] Inst Maternal & Child Hlth IRCCS Burlo Garofolo, Trieste, Italy
关键词
Methylmercury; Speciation; Prenatal exposure; Neurodevelopment; Apolipoprotein E (ApoE); MATERNAL FISH CONSUMPTION; METHYL-MERCURY; UMBILICAL-CORD; DEVELOPMENTAL NEUROTOXICITY; SEAFOOD CONSUMPTION; INORGANIC MERCURY; METHYLMERCURY; BLOOD; BIOMARKERS; HEALTH;
D O I
10.1016/j.envres.2019.108627
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
In recent years, several studies have addressed the issue of prenatal exposure to methylmercury (MeHg); however, few have actually analysed MeHg blood concentrations. Our study population included mothers and their new-borns from Slovenia (central region; N = 584) and Croatia (coastal region; N = 234). We have measurements of total Hg (THg) and MeHg in maternal hair, maternal peripheral blood, and cord blood. Cord blood Hg concentrations were low to moderate (median THg = 1.84 ng/g and MeHg = 1.69 ng/g). The proportion of THg as MeHg (%Melig) in maternal and cord blood varied between 4% and 100% (coefficient of variation, CV = 32%) and between 8% and 100% (CV = 20%), respectively. Our data shows that variability of %MeHg was higher at lower blood THg levels. Concentrations of MeHg in maternal blood and cord blood were highly correlated (R-s = 0.943), in the case of inorganic Hg correlation was significant but weaker (R-s = 0.198). MeHg levels in maternal blood and cord blood were positively associated with seafood intake, maternal age, and negatively associated with pre-pregnancy BMI. Additionally, MeHg in maternal blood was positively associated with plasma selenium levels, and cord blood MeHg was negatively associated with parity. The results of multiple linear regression models showed that speciation analysis provides more defined estimation of prenatal exposure in association modelling. Associations between Hg exposure and cognitive performance of children (assessed using Bayley Scales of Infant and Toddler development) adjusted for maternal or child Apolipoprotein E genotypes showed higher model R-2 and lower p-values when adjusted for MeHg compared to THg. This study demonstrates that Hg speciation improves the association between exposure and possible negative health effects.
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页数:10
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