Improvement of systemic lupus erythematosus in dogs with canine adipose-derived stem cells

被引：1
作者：
Ko, Minho [1 ,2 ]
Kim, Tae Hyeong [3 ]
Kim, Yoonhwan [1 ,2 ]
Kim, Doo [1 ,2 ]
Ahn, Jin-Ok [1 ,2 ]
Kang, Byling-Jae [4 ]
Choi, Sooyoung [5 ]
Park, Inchul [5 ]
Choi, Jung Hoon [3 ]
Chung, Jin Young [1 ,2 ]
机构：
[1] Kangwon Natl Univ, Dept Vet Internal Med, Coll Vet Med, Chuncheon Si, Gangwon Do, South Korea
[2] Kangwon Natl Univ, Inst Vet Sci, Coll Vet Med, Chuncheon Si, Gangwon Do, South Korea
[3] Kangwon Natl Univ, Dept Vet Anat, Coll Vet Med, Chuncheon Si, Gangwon Do, South Korea
[4] Kangwon Natl Univ, Dept Vet Surg, Coll Vet Med, Chuncheon Si, Gangwon Do, South Korea
[5] Kangwon Natl Univ, Dept Vet Diagnost Imaging, Coll Vet Med, Gangwondo, South Korea
来源：
VETERINARNI MEDICINA | 2019年 / 64卷 / 10期
基金：
新加坡国家研究基金会;
关键词：
dog; SLE; stem cell therapy; INDUCED LIVER-INJURY; RISK-FACTORS;
D O I：
10.17221/46/2019-VETMED
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
A 6-year-old, intact female, Maltese presented with limited movement of the hind limbs and intermittent pruritus for three months. The patient was diagnosed with systemic lupus erythematosus. Conventional immunosuppressive therapy was attempted for 70 days; however, the patient still suffered from life-threatening pancreatitis and hepatopathy. Therefore, we tried canine adipose-derived mesenchymal stem cells for immunomodulation and liver protection. After 6-months of the stem cell therapy, the patient's walking and hepatopathy improved. These findings indicate that stem cell therapy may be another option for systemic lupus erythematosus in dogs.
引用
收藏
页码：462 / 466
页数：5
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