Reconstruction of substrate's diffusion landscape by the wavelet analysis of single particle diffusion tracks

We propose an approach to analysing single trajectories of a particle, which moves randomly on a landscape distinct parts of which result in sufficiently various diffusion coefficients. The method based on the mapping the cumulative sum of step-wise elementary displacement squared into a complex oscillating function with the subsequent continuous wavelet analysis of the later allows the localization of relatively homogeneous sub-regions and determining values of the diffusion coefficient within each such sub-region. This approach is applied to demonstrable test examples as well as to the reconstruction of the biological membrane's properties from the real data of single molecule walk tracing. (C) 2019 Elsevier B.V. All rights reserved.