1,3-dipolar cycloadditions of azides and alkynes: A universal ligation tool in polymer and materials science

In 2001, Sharpless and co-workers introduced click chemistry, a new approach in organic synthesis that involves a handful of almost perfect chemical reactions. Among these carefully selected reactions, Huisgen 1,3-dipolar cycloadditions were shown to be the most effective and versatile and thus became the prime example of click chemistry. Hence, these long-neglected reactions were suddenly re-established in organic synthesis and, in particular, have gained popularity in materials science. The number of publications dealing with click chemistry has grown exponentially over the last two years. The Minireview discusses whether click chemistry is a miracle tool or an ephemeral trend. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.