DNA Nanotechnology and Computer Systems of Nucleic Acids

Structural DNA nanotechnology (SDN) has attracted the attention of scientists in different research fields. Motifs are designed for various purposes, such as drug delivery, capturing proteins, templates for DNA nanotechnology, etc. However, DNA motif design does not simply depend on physical models or the human imagination if the desired structure is complicated. Structuring and modeling by using fast-growing computer technologies are essential and desirable for the entire community. In this paper, we present a review of the current research in the field in terms of the structure of DNA, molecular modeling, and various computer programs aiming to design, analyze and evaluate nucleic acid structures, explain how they interact and predict the macrostructures formed by a number of molecular units in DNA nanotechnology.