Recurrent pregnancy loss: A disease of inflammation and coagulation

被引：135
作者：
Kwak-Kim, Joanne [1 ,2 ]
Yang, Kwang Moon [1 ,3 ]
Gilman-Sachs, Alice [2 ]
机构：
[1] Rosalind Franklin Univ Med & Sci, Chicago Med Sch, Dept Obstet & Gynecol, N Chicago, IL 60064 USA
[2] Rosalind Franklin Univ Med & Sci, Chicago Med Sch, Dept Microbiol & Immunol, N Chicago, IL 60064 USA
[3] Kwandong Univ, Coll Med, Cheil Gen Hosp & Womens Healthcare Ctr, Dept Obstet & Gynecol, Seoul, South Korea
来源：
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH | 2009年 / 35卷 / 04期
关键词：
inflammation; NK cells; PAI-1; recurrent pregnancy loss; Th1 immune response; thrombosis; NATURAL-KILLER-CELLS; MOLECULAR-WEIGHT HEPARIN; ACTIVATED PROTEIN-C; POLYCYSTIC-OVARY-SYNDROME; MATERNAL-FETAL INTERFACE; REGULATORY T-CELLS; ANNEXIN-V BINDING; X DBA/2 MICE; SPONTANEOUS-ABORTION; INTRAVENOUS IMMUNOGLOBULIN;
D O I：
10.1111/j.1447-0756.2009.01079.x
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Recurrent pregnancy loss (RPL) is one of the most common obstetrical complications. Multiple etiologies, such as endocrine, anatomic, genetic, hematological and immunological causes have been reported for this devastating disease. However, over half of the cases remain unexplained. Thrombotic/inflammatory processes are often observed at the maternal-fetal interface as the final pathological assault in many cases of RPL, including those of unexplained etiologies. In the present paper, cellular immune responses (T, natural killer [NK], natural killer-T [NKT], regulatory T [Treg] cells and their cytokines) and autoimmune abnormalities of women with RPL are reviewed. In addition, metabolic diseases and hematological conditions which often lead to thrombotic/inflammatory conditions are discussed in association with RPL. Finally, current therapeutic options for RPL are reviewed.
引用
收藏
页码：609 / 622
页数：14
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