Knockdown of TRIM32 Protects Hippocampal Neurons from Oxygen-Glucose Deprivation-Induced Injury

被引:19
作者
Wei, Liang [1 ,2 ,3 ,4 ]
Zhang, Jian-shui [3 ]
Ji, Sheng-feng [3 ]
Xu, Hao [1 ,2 ]
Zhao, Zhao-hua [1 ,2 ]
Zhang, Li [1 ,2 ]
Pang, Long [1 ,2 ]
Zhang, Jun-feng [1 ,2 ,5 ]
Yang, Peng-bo [3 ]
Ma, Hai [4 ]
机构
[1] Xian Med Univ, Dept Human Anat, Xian 710021, Shaanxi, Peoples R China
[2] Xian Med Univ, Shaanxi Key Lab Brain Disorders, Xian 710021, Shaanxi, Peoples R China
[3] Xi An Jiao Tong Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Human Anat Sr Histoembryol, Xian 710061, Shaanxi, Peoples R China
[4] Changan Hosp, Dept Internal Neurol, Xian 710018, Shaanxi, Peoples R China
[5] Xian Med Univ, Inst Basic & Translat Med, Shaanxi Key Lab Ischem Cardiovasc Dis, Xian 710021, Shaanxi, Peoples R China
基金
中国国家自然科学基金;
关键词
Tripartite totif 32 (TRIM32); Cerebral ischemia reperfusion (I; R) injury; Hippocampal neurons; Oxygen-glucose deprivation; reperfusion (OGD; R); Oxidative stress; Nrf2 signaling pathway; MYOCARDIAL-ISCHEMIA; BRAIN; NRF2; EXPRESSION; DIFFERENTIATION; STROKE;
D O I
10.1007/s11064-019-02857-7
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Tripartite motif 32 (TRIM32) is a member of TRIM family that plays a potential role in neural regeneration. However, the biological function of TRIM32 in cerebral ischemia reperfusion injury has not been investigated. In the present study, we evaluated the expression level of TRIM32 in hippocampal neurons following oxygen-glucose deprivation/reperfusion (OGD/R). The results showed that TRIM32 expression was significantly elevated in hippocampal neurons subjected to OGD/R as compared to the neurons cultured in the normoxia condition. To further evaluate the role of TRIM32, hippocampal neurons were transfected with TRIM32 small interfering RNA (si-TRIM32) to knock down TRIM32. We found that knockdown of TRIM32 improved cell viability of OGD/R-stimulated hippocampal neurons. Generation of reactive oxygen species was decreased, while contents of superoxide dismutase and glutathione peroxidase were increased after si-TRIM32 transfection. Knockdown of TRIM32 suppressed cell apoptosis, as proved by the increased bcl-2 expression along with decreased bax expression and caspase-3 activity. We also found that TRIM32 knockdown enhanced OGD/R-induced activation of Nrf2 signaling pathway in hippocampal neurons. Furthermore, siRNA-Nrf2 was transfected to knock down Nrf2. SiRNA-Nrf2 transfection reversed the protective effects of TRIM32 knockdown on neurons. These data suggested that knockdown of TRIM32 protected hippocampal neurons from OGD/R-induced oxidative injury through activating Nrf2 signaling pathway.
引用
收藏
页码:2182 / 2189
页数:8
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