Epithelial to Mesenchymal Transition in Renal Cell Carcinoma: Implications for Cancer Therapy

被引：82

作者：

Piva, Francesco ^{[1
]}

Giulietti, Matteo ^{[1
]}

Santoni, Matteo ^{[2
]}

Occhipinti, Giulia ^{[1
]}

Scarpelli, Marina ^{[3
]}

Lopez-Beltran, Antonio ^{[4
]}

Cheng, Liang ^{[5
]}

Principato, Giovanni ^{[1
]}

Montironi, Rodolfo ^{[3
]}

机构：

[1] Polytech Univ Marche Reg, Dept Specialist Clin & Odontostomatol Sci, I-60131 Ancona, Italy

[2] Univ Politecn Marche, AOU Osped Riuniti, Clin Oncol Med, Via Conca 71, I-60126 Ancona, Italy

[3] Polytech Univ Marche Reg, Sch Med, United Hosp, Sect Pathol Anat, I-60131 Ancona, Italy

[4] Univ Cordoba, Fac Med, Dept Pathol & Surg, Cordoba, Spain

[5] Indiana Univ Sch Med, Dept Pathol & Lab Med, Indianapolis, IN 46202 USA

来源：

MOLECULAR DIAGNOSIS & THERAPY | 2016年 / 20卷 / 02期

关键词：

INTEGRIN-LINKED KINASE; NECROSIS-FACTOR-ALPHA; DOWN-REGULATION; TUMOR-SUPPRESSOR; FOCAL ADHESION; EXPRESSION; TARGET; INVASION; MUC1; METASTASIS;

D O I：

10.1007/s40291-016-0192-5

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Epithelial-to-mesenchymal transition (EMT) is a developmentally vital reversible process by which fully differentiated cells lose their epithelial features and acquire a migratory mesenchymal phenotype. EMT contributes to the metastatic potential of tumors. The expression profile and other biological properties of EMT suggest potential targets for cancer therapy, including in renal-cell carcinoma (RCC). The preclinical and clinical results have substantiated the promises that dysregulated elements leading to EMT can be a potential target in RCC patients. In this study, we illustrated the pathogenic and prognostic role of EMT in RCC. In addition, we reconstructed, by literature analysis, the different pathways implicated in the EMT process, thus supporting the rational for future EMT-directed therapeutic approaches for RCC patients.

引用

页码：111 / 117

页数：7

共 46 条

[1] MUC1, a New Hypoxia Inducible Factor Target Gene, Is an Actor in Clear Renal Cell Carcinoma Tumor Progression [J].

Aubert, Sebastien ;

Fauquette, Valerie ;

Hemon, Brigitte ;

Lepoivre, Rejane ;

Briez, Nicolas ;

Bernard, David ;

Van Seuningen, Isabelle ;

Leroy, Xavier ;

Perrais, Michael .

CANCER RESEARCH, 2009, 69 (14) :5707-5715

[2]

Bielecka Zofia F, 2014, Curr Signal Transduct Ther, V8, P218

[3] Sarcomatoid conversion of clear cell renal cell carcinoma in relation to epithelial-to-mesenchymal transition [J].

Bostrom, Anna-Karin ;

Moller, Christina ;

Nilsson, Elise ;

Elfving, Peter ;

Axelson, Hakan ;

Johansson, Martin E. .

HUMAN PATHOLOGY, 2012, 43 (05) :708-719

[4] MicroRNA-21 stimulates epithelial-to-mesenchymal transition and tumorigenesis in clear cell renal cells [J].

Cao, Jian ;

Liu, Jun ;

Xu, Ran ;

Zhu, Xuan ;

Liu, Lei ;

Zhao, Xiaokun .

MOLECULAR MEDICINE REPORTS, 2016, 13 (01) :75-82

[5] Expression and Prognostic Significance of a Comprehensive Epithelial-Mesenchymal Transition Gene Set in Renal Cell Carcinoma [J].

Chen, Dong ;

Gassenmaier, Maximilian ;

Maruschke, Matthias ;

Riesenberg, Rainer ;

Pohla, Heike ;

Stief, Christian G. ;

Zimmermann, Wolfgang ;

Buchner, Alexander .

JOURNAL OF UROLOGY, 2014, 191 (02) :479-486

[6] Sarcomatoid renal cell carcinoma is an example of epithelial-mesenchymal transition [J].

Conant, Joanna L. ;

Peng, Zhihua ;

Evans, Mark F. ;

Naud, Shelly ;

Cooper, Kumarasen .

JOURNAL OF CLINICAL PATHOLOGY, 2011, 64 (12) :1088-1092

[7] Comprehensivemolecular characterization of clear cell renal cell carcinoma [J].

Creighton, Chad J. ;

Morgan, Margaret ;

Gunaratne, Preethi H. ;

Wheeler, David A. ;

Gibbs, Richard A. ;

Robertson, A. Gordon ;

Chu, Andy ;

Beroukhim, Rameen ;

Cibulskis, Kristian ;

Signoretti, Sabina ;

Vandin, Fabio ;

Wu, Hsin-Ta ;

Raphael, Benjamin J. ;

Verhaak, Roel G. W. ;

Tamboli, Pheroze ;

Torres-Garcia, Wandaliz ;

Akbani, Rehan ;

Weinstein, John N. ;

Reuter, Victor ;

Hsieh, James J. ;

Brannon, A. Rose ;

Hakimi, A. Ari ;

Jacobsen, Anders ;

Ciriello, Giovanni ;

Reva, Boris ;

Ricketts, Christopher J. ;

Linehan, W. Marston ;

Stuart, Joshua M. ;

Rathmell, W. Kimryn ;

Shen, Hui ;

Laird, Peter W. ;

Muzny, Donna ;

Davis, Caleb ;

Morgan, Margaret ;

Xi, Liu ;

Chang, Kyle ;

Kakkar, Nipun ;

Trevino, Lisa R. ;

Benton, Susan ;

Reid, Jeffrey G. ;

Morton, Donna ;

Doddapaneni, Harsha ;

Han, Yi ;

Lewis, Lora ;

Dinh, Huyen ;

Kovar, Christie ;

Zhu, Yiming ;

Santibanez, Jireh ;

Wang, Min ;

Hale, Walker .

NATURE, 2013, 499 (7456) :43-+

[8]

Dumanskiy Y. V., 2013, Experimental Oncology, V35, P325

[9] Protein Expression of ZEB2 in Renal Cell Carcinoma and Its Prognostic Significance in Patient Survival [J].

Fang, Yong ;

Wei, Jinhuan ;

Cao, Jiazheng ;

Zhao, Hongwei ;

Liao, Bing ;

Qiu, Shaopeng ;

Wang, Daohu ;

Luo, Junhang ;

Chen, Wei .

PLOS ONE, 2013, 8 (05)

[10] MUC1 drives epithelial-mesenchymal transition in renal carcinoma through Wnt/β-catenin pathway and interaction with SNAIL promoter [J].

Gnemmi, Viviane ;

Bouillez, Audrey ;

Gaudelot, Kelly ;

Hemon, Brigitte ;

Ringot, Belinda ;

Pottier, Nicolas ;

Glowacki, Francois ;

Villers, Arnauld ;

Vindrieux, David ;

Cauffiez, Christelle ;

Van Seuningen, Isabelle ;

Bernard, David ;

Leroy, Xavier ;

Aubert, Sebastien ;

Perrais, Michael .

CANCER LETTERS, 2014, 346 (02) :225-236

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