The kinetic resolution of allylic alcohols by a non-enzymatic acylation catalyst; application to natural product synthesis

被引：107

作者：

Bellemin-Laponnaz, S ^{[1
]}

Tweddell, J ^{[1
]}

Ruble, JC ^{[1
]}

Breitling, FM ^{[1
]}

Fu, GC ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

CHEMICAL COMMUNICATIONS | 2000年 / 12期

关键词：

D O I：

10.1039/b002041i

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A planar-chiral DMAP derivative is shown to serve as an effective catalyst for the kinetic resolution of allylic alcohols; to illustrate its practical utility, the catalyst is applied to the resolution of two alcohols that have been employed as intermediates in recent natural product total syntheses.

引用

页码：1009 / 1010

页数：2

共 22 条

[1]

BORMAN S, 1998, CHEM ENG NEWS 1214, P15

[2]

BORMAN S, 2000, CHEM ENG NEWS 0131, P7

[3] Enantioselective synthesis of beta-substituted butyric acid derivatives via orthoester Claisen rearrangement of enzymatically resolved allylic alcohols: application to the synthesis of (R)-(-)-baclofen [J].