Distribution of lymph node metastases in esophageal carcinoma [TIGER study]: study protocol of a multinational observational study

被引：69

作者：

Hagens, Eliza R. C. ^{[1
]}

Henegouwen, Mark I. van Berge ^{[1
]}

van Sandick, Johanna W. ^{[2
]}

Cuesta, Miguel A. ^{[3
]}

van der Peet, Donald L. ^{[3
]}

Heisterkamp, Joos ^{[4
]}

Nieuwenhuijzen, Grard A. P. ^{[5
]}

Rosman, Camiel ^{[6
]}

Scheepers, Joris J. G. ^{[7
]}

Sosef, Meindert N. ^{[8
]}

van Hillegersberg, Richard ^{[9
]}

Lagarde, Sjoerd M. ^{[10
]}

Nilsson, Magnus ^{[11
]}

Rasanen, Jari ^{[12
]}

Nafteux, Philippe ^{[13
]}

Pattyn, Piet ^{[14
]}

Hoelscher, Arnulf H. ^{[15
]}

Schroeder, Wolfgang ^{[16
]}

Schneider, Paul M. ^{[17
,18
]}

Mariette, Christophe ^{[19
]}

Castoro, Carlo ^{[20
]}

Bonavina, Luigi ^{[21
]}

Rosati, Riccardo ^{[22
]}

de Manzoni, Giovanni ^{[23
]}

Mattioli, Sandro ^{[24
]}

Roig Garcia, Josep ^{[25
]}

Pera, Manuel ^{[26
]}

Griffin, Michael ^{[27
]}

Wilkerson, Paul ^{[28
]}

Chaudry, M. Asif ^{[29
]}

Sgromo, Bruno ^{[30
]}

Tucker, Olga ^{[31
]}

Cheong, Edward ^{[32
]}

Moorthy, Krishna ^{[33
]}

Walsh, Thomas N. ^{[34
]}

Reynolds, John ^{[35
]}

Tachimori, Yuji ^{[36
]}

Inoue, Haruhiro ^{[37
]}

Matsubara, Hisahiro ^{[38
]}

Kosugi, Shin-ichi ^{[39
]}

Chen, Haiquan ^{[40
]}

Law, Simon Y. K. ^{[41
]}

Pramesh, C. S. ^{[42
]}

Puntambekar, Shailesh P. ^{[43
]}

Murthy, Sudish ^{[44
]}

Linden, Philip ^{[45
]}

Hofstetter, Wayne L. ^{[46
]}

Kuppusamy, Madhan K. ^{[47
]}

Shen, K. Robert ^{[48
]}

Darling, Gail E. ^{[49
]}

机构：

[1] Univ Amsterdam, Amsterdam UMC, Canc Ctr Amsterdam, Dept Surg, Meibergdreef 9, Amsterdam, Netherlands

[2] Netherlands Canc Inst, Amsterdam, Netherlands

[3] Vrije Univ Amsterdam, Amsterdam UMC, Dept Surg, De Boelelaan 1117, Amsterdam, Netherlands

[4] Elisabeth TweeSteden Ziekenhuis, Tilburg, Netherlands

[5] Catharina Hosp, Eindhoven, Netherlands

[6] Radboud Univ Nijmegen, Med Ctr Nijmegen, Nijmegen, Netherlands

[7] Reinier de Graaf Gasthuis, Delft, Netherlands

[8] Atrium Med Ctr, Heerlen, Netherlands

[9] Univ Med Ctr Utrecht, Utrecht, Netherlands

[10] Erasmus MC, Rotterdam, Netherlands

[11] Karolinska Inst, Stockholm, Sweden

[12] Hosp Dist Helsinki & Uusimaa, Helsinki, Finland

[13] Univ Ziekenhuis Leuven, Leuven, Belgium

[14] Univ Ziekenhuis, Ghent, Belgium

[15] Agaples Markus Krankenhuis, Frankfurt, Germany

[16] Uniklin Koln, Cologne, Germany

[17] Triemli Med Ctr, Zurich, Switzerland

[18] Hirslanden Med Ctr, Zurich, Switzerland

[19] Univ Hosp C Huriez, Pl Verdun, Lille, France

[20] Humanitas Univ Hosp, Milan, Italy

[21] Univ Milan, Ist Ricovero & Cura Carattere Sci, Policlin San Donato, Milan, Italy

[22] Osped San Raffaelo, Milan, Italy

[23] Univ Verona, Verona, Italy

[24] Univ Bologna, Bologna, Italy

[25] Hosp Josep Trueta, Girona, Spain

[26] Hosp Univ del Mar, Barcelona, Spain

[27] New Castle Upon Tyne Hosp, Royal Victoria Infirm, New Castle, England

[28] Univ Hosp Bristol, Bristol, Avon, England

[29] Royal Marsden, London, England

[30] Oxford Univ Hosp, Oxford, England

[31] Heart England Fdn Trust, Birmingham, W Midlands, England

[32] Norfolk & Norwich Univ Hosp, Norwich, Norfolk, England

[33] Imperial Coll, London, England

[34] Connolly Hosp Blanchardstown, Dublin, Ireland

[35] Trinity Coll Dublin, Dublin, Ireland

[36] Natl Canc Ctr, Tokyo, Japan

[37] Showa Univ, Northern Yokohama Hosp, Yokohama, Kanagawa, Japan

[38] Chiba Univ, Grad Sch Med, Chiba, Japan

[39] Niigata Univ Med & Dent Hosp, Uonuma Inst Community Med, Minami Uonuma, Japan

[40] Fudan Univ, Shanghai Canc Ctr, Shanghai, Peoples R China

[41] Univ Hong Kong, Pok Fu Lam, Hong Kong, Peoples R China

[42] Tata Mem Hosp, Mumbai, Maharashtra, India

[43] Galaxy Care Laparoscopy Inst, Pune, Maharashtra, India

[44] Cleveland Clin, Cleveland, OH 44106 USA

[45] Univ Hosp, Cleveland, OH USA

[46] MD Anderson, Houston, TX USA

[47] Virginia Mason Med Ctr, Seattle, WA 98101 USA

[48] Mayo Clin, Rochester, MN USA

[49] Univ Toronto, Toronto, ON, Canada

[50] Inst Nacl Canc, Rio De Janeiro, Brazil

来源：

BMC CANCER | 2019年 / 19卷 / 1期

关键词：

Esophageal cancer; Lymph node metastases; Lymphadenectomy; Esophagectomy; SQUAMOUS-CELL; CANCER; ADENOCARCINOMA; PATTERN; SPREAD; LYMPHADENECTOMY; DISSECTION; IMPACT;

D O I：

10.1186/s12885-019-5761-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BackgroundAn important parameter for survival in patients with esophageal carcinoma is lymph node status. The distribution of lymph node metastases depends on tumor characteristics such as tumor location, histology, invasion depth, and on neoadjuvant treatment. The exact distribution is unknown. Neoadjuvant treatment and surgical strategy depends on the distribution pattern of nodal metastases but consensus on the extent of lymphadenectomy has not been reached. The aim of this study is to determine the distribution of lymph node metastases in patients with resectable esophageal or gastro-esophageal junction carcinoma in whom a transthoracic esophagectomy with a 2- or 3-field lymphadenectomy is performed. This can be the foundation for a uniform worldwide staging system and establishment of the optimal surgical strategy for esophageal cancer patients.MethodsThe TIGER study is an international observational cohort study with 50 participating centers. Patients with a resectable esophageal or gastro-esophageal junction carcinoma in whom a transthoracic esophagectomy with a 2- or 3-field lymphadenectomy is performed in participating centers will be included. All lymph node stations will be excised and separately individually analyzed by pathological examination. The aim is to include 5000 patients. The primary endpoint is the distribution of lymph node metastases in esophageal and esophago-gastric junction carcinoma specimens following transthoracic esophagectomy with at least 2-field lymphadenectomy in relation to tumor histology, tumor location, invasion depth, number of lymph nodes and lymph node metastases, pre-operative diagnostics, neo-adjuvant therapy and (disease free) survival.DiscussionThe TIGER study will provide a roadmap of the location of lymph node metastases in relation to tumor histology, tumor location, invasion depth, number of lymph nodes and lymph node metastases, pre-operative diagnostics, neo-adjuvant therapy and survival. Patient-tailored treatment can be developed based on these results, such as the optimal radiation field and extent of lymphadenectomy based on the primary tumor characteristics.Trial registrationNCT03222895, date of registration: July 19th, 2017.

引用

页数：8

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