Synthesis of a Neonicotinoid Pesticide Derivative via Chemoenzymatic Dynamic Kinetic Resolution

被引：20

作者：

Krumlinde, Patrik ^{[1
]}

Bogar, Krisztian ^{[2
]}

Backvall, Jan-E ^{[1
]}

机构：

[1] Stockholm Univ, Dept Organ Chem, Arrhenius Lab, SE-10691 Stockholm, Sweden

[2] AstraZeneca R&D Sodertalje, Med Chem, Discovery, SE-15185 Sodertalje, Sweden

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 74卷 / 19期

基金：

瑞典研究理事会;

关键词：

SECONDARY ALCOHOLS; INSECTICIDE;

D O I：

10.1021/jo9014276

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chemoenzymatic dynamic kinetic resolution (DKR) via combined ruthenium and enzyme catalysis was used in the key step of a synthesis of a neonicotinoid pesticide derivative (S)-3. The DKR was carried Out under mild conditions with low catalyst loading. The method gives (S)-3 in high enantiomeric excess (98%).

引用

页码：7407 / 7410

页数：4

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