Isolation and structural elucidation of callipeltins J-M:: antifungal peptides from the marine sponge Latrunculia sp.

被引：37

作者：

D'Auria, Maria Valeria

Sepe, Valentina

D'Orsi, Rosa

Bellotta, Filomena

Debitus, Cecile

Zampella, Angela

机构：

[1] Univ Naples Federico II, Dipartimento Chim Sostanze Nat, I-80131 Naples, Italy

[2] IRD ORSTOM, Ctr Noumea, Noumea, New Caledonia

来源：

TETRAHEDRON | 2007年 / 63卷 / 01期

关键词：

callipeltin; peptides; antifungal;

D O I：

10.1016/j.tet.2006.10.032

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Continued investigation of the polar extracts of the marine sponge Latrunculia sp. has resulted in the discovery of callipeltins J-M. The new structures were determined by interpretation of their NMR and MS data. The stereochemistry of the unusual 3-methylglutamine residue in callipeltins J and K was secured by stereoselective synthesis and Marfey's LC-MS analysis. (c) 2006 Elsevier Ltd. All fights reserved.

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页码：131 / 140

页数：10

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