Hepatic artery chemotherapy for colorectal liver metastases: technical considerations and review of clinical trials

被引：51

作者：

Skitzki, JJ ^{[1
]}

Chang, AE ^{[1
]}

机构：

[1] Univ Michigan, Med Ctr, Div Surg Oncol, Comprehens Canc Ctr 3302, Ann Arbor, MI 48109 USA

来源：

SURGICAL ONCOLOGY-OXFORD | 2002年 / 11卷 / 03期

关键词：

colorectal cancer; liver metastasis; regional chemotherapy;

D O I：

10.1016/S0960-7404(02)00032-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hepatic artery infusion (HAI) of chemotherapeutic agents for colorectal hepatic metastases is associated with significantly higher response rates compared to systemic chemotherapy. However, response rates have not consistently translated into improved survival. Several randomized trials have evaluated the implantable pump for treating unresectable colorectal hepatic metastases. Meta-analysis of these studies have demonstrated an improved survival advantage with pump therapy as well as improved quality of life. Recent studies of HAI of chemotherapy as adjuvant therapy following liver metastases resection have also demonstrated a potential survival advantage. Toxicities of HAI can be treatment limiting, but measures have emerged for overcoming these side effects. These randomized clinical trials have established HAI as a reasonable therapeutic option in patients with unresectable disease, and as adjuvant therapy in patients with resectable disease. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：123 / 135

页数：13

共 90 条

[11] A TOTALLY IMPLANTABLE DRUG INFUSION DEVICE - LABORATORY AND CLINICAL-EXPERIENCE USING A MODEL WITH SINGLE FLOW-RATE AND NEW DESIGN FOR MODULATED INSULIN INFUSION [J].

BUCHWALD, H ;

ROHDE, TD ;

DORMAN, FD ;

SKAKOON, JG ;

WIGNESS, BD ;

PROSL, FR ;

TUCKER, EM ;

RUBLEIN, TG ;

BLACKSHEAR, PJ ;

VARCO, RL .

DIABETES CARE, 1980, 3 (02) :351-358

[12]

BUROKER T, 1976, CANCER TREAT REP, V60, P1277

[13]

BURROWS JH, 1967, CANCER, V20, P1886, DOI 10.1002/1097-0142(196711)20:11<1886::AID-CNCR2820201114>3.0.CO

[14]

2-S

[15] REGIONAL INFUSION CHEMOTHERAPY OF HEPATIC METASTASES FROM CARCINOMA OF COLON [J].

CADY, B ;

OBERFIELD, RA .

AMERICAN JOURNAL OF SURGERY, 1974, 127 (02) :220-227

[16] REGIONAL CHEMOTHERAPY DEVICES - EFFECT OF EXPERIENCE AND ANATOMY ON COMPLICATIONS [J].

CAMPBELL, KA ;

BURNS, RC ;

SITZMANN, JV ;

LIPSETT, PA ;

GROCHOW, LB ;

NIEDERHUBER, JE .

JOURNAL OF CLINICAL ONCOLOGY, 1993, 11 (05) :822-826

[17] A PROSPECTIVE RANDOMIZED TRIAL OF REGIONAL VERSUS SYSTEMIC CONTINUOUS 5-FLUORODEOXYURIDINE CHEMOTHERAPY IN THE TREATMENT OF COLORECTAL LIVER METASTASES [J].

CHANG, AE ;

SCHNEIDER, PD ;

SUGARBAKER, PH ;

SIMPSON, C ;

CULNANE, M ;

STEINBERG, SM .

ANNALS OF SURGERY, 1987, 206 (06) :685-693

[18]

CHANG AE, 1987, CANCER CHEMOTHERAPY, P435

[19]

CLARKSON B, 1962, CANCER, V15, P472, DOI 10.1002/1097-0142(196205/06)15:3<472::AID-CNCR2820150307>3.0.CO

[20]

2-S

← 1 2 3 4 5 6 7 8 9 →