Lipoic Acid Gold Nanoparticles Functionalized with Organic Compounds as Bioactive Materials

被引：28
作者：
Turcu, Ioana [1 ]
Zarafu, Irina [1 ]
Popa, Marcela [2 ,3 ]
Chifiriuc, Mariana Carmen [2 ,3 ]
Bleotu, Coralia [2 ,4 ]
Culita, Daniela [5 ]
Ghica, Corneliu [6 ]
Ionita, Petre [1 ,5 ]
机构：
[1] Univ Bucharest, Dept Organ Chem Biochem & Catalysis, 90-92 Panduri, Bucharest 050663, Romania
[2] Univ Bucharest, Fac Biol, Microbiol Dept, 1-3 Portocalelor Way, Bucharest 060101, Romania
[3] Univ Bucharest ICUB, Res Inst, 91-95 Spl Independentei, Bucharest 050095, Romania
[4] Romanian Acad, Stefan S Nicolau Inst Virol IVN, 285 Mihai Bravu Ave,Sect 3,PO 77,POB 201, Bucharest 030304, Romania
[5] Inst Phys Chem, 202 Spl Independentei, Bucharest 060021, Romania
[6] Natl Inst Mat Phys, Lab Atom Struct & Defects Adv Mat, Atomistilor 105 Bis, Magurele 077125, Romania
来源：
NANOMATERIALS | 2017年 / 7卷 / 02期
关键词：
gold nanoparticles; lipoic acid; thioctic acid; antimicrobial; cytotoxicity; cellular cycle; ANTIMICROBIAL ACTIVITY; ELECTROPORATION; COMPLEXES; EFFICACY; DELIVERY;
D O I：
10.3390/nano7020043
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Water soluble gold nanoparticles protected by lipoic acid were obtained and further functionalized by standard coupling reaction with 1-naphtylamine, 4-aminoantipyrine, and 4 0 -aminobenzo-15-crown-5 ether. Derivatives of lipoic acid with 1-naphtylamine, 4-aminoantipyrine, and 4 0 -aminobenzo-15-crown-5 ether were also obtained and characterized. All these were tested for their antimicrobial activity, as well as for their influence on mammalian cell viability and cellular cycle. In all cases a decreased antimicrobial activity of the obtained bioactive nanoparticles was observed as compared with the organic compounds, proving that a possible inactivation of the bioactive groups could occur during functionalization. However, both the gold nanoparticles as well as the functionalized bioactive nanosystems proved to be biocompatible at concentrations lower than 50 mu g/mL, as revealed by the cellular viability and cell cycle assay, demonstrating their potential for the development of novel antimicrobial agents.
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页数：9
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