Hepatitis C virus relies on lipoproteins for its life cycle

被引：36

作者：

Grassi, Germana ^{[1
]}

Di Caprio, Giorgia ^{[1
,2
]}

Fimia, Gian Maria ^{[1
,3
]}

Ippolito, Giuseppe ^{[1
]}

Tripodi, Marco ^{[1
,2
]}

Alonzi, Tonino ^{[1
]}

机构：

[1] Natl Inst Infect Dis L Spallanzani IRCCS, I-00149 Rome, Italy

[2] Univ Roma La Sapienza, Cenci Bolognetti Fdn, Inst Pasteur, Dept Cellular Biotechnol & Hematol, I-00149 Rome, Italy

[3] Univ Salento, Dept Biol & Environm Sci & Technol DiSTeBA, I-73100 Lecce, Italy

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2016年 / 22卷 / 06期

关键词：

Apolipoproteins; Hepatitis C virus; Lipid metabolism; Lipoproteins; Review; LOW-DENSITY-LIPOPROTEIN; B TYPE-I; 2-DIMENSIONAL GEL-ELECTROPHORESIS; ADAPTIVE IMMUNE-RESPONSES; TO-CELL TRANSMISSION; APOLIPOPROTEIN-E; HUMAN HEPATOCYTES; CORE PROTEIN; CANDIDATE RECEPTOR; NATURAL-HISTORY;

D O I：

10.3748/wjg.v22.i6.1953

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Hepatitis C virus (HCV) infects over 150 million people worldwide. In most cases, HCV infection becomes chronic causing liver disease ranging from fibrosis to cirrhosis and hepatocellular carcinoma. Viral persistence and pathogenesis are due to the ability of HCV to deregulate specific host processes, mainly lipid metabolism and innate immunity. In particular, HCV exploits the lipoprotein machineries for almost all steps of its life cycle. The aim of this review is to summarize current knowledge concerning the interplay between HCV and lipoprotein metabolism. We discuss the role played by members of lipoproteins in HCV entry, replication and virion production.

引用

页码：1953 / 1965

页数：13

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