Hepatitis C virus relies on lipoproteins for its life cycle

被引：35

作者：

Grassi, Germana ^{[1
]}

Di Caprio, Giorgia ^{[1
,2
]}

Fimia, Gian Maria ^{[1
,3
]}

Ippolito, Giuseppe ^{[1
]}

Tripodi, Marco ^{[1
,2
]}

Alonzi, Tonino ^{[1
]}

机构：

[1] Natl Inst Infect Dis L Spallanzani IRCCS, I-00149 Rome, Italy

[2] Univ Roma La Sapienza, Cenci Bolognetti Fdn, Inst Pasteur, Dept Cellular Biotechnol & Hematol, I-00149 Rome, Italy

[3] Univ Salento, Dept Biol & Environm Sci & Technol DiSTeBA, I-73100 Lecce, Italy

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2016年 / 22卷 / 06期

关键词：

Apolipoproteins; Hepatitis C virus; Lipid metabolism; Lipoproteins; Review; LOW-DENSITY-LIPOPROTEIN; B TYPE-I; 2-DIMENSIONAL GEL-ELECTROPHORESIS; ADAPTIVE IMMUNE-RESPONSES; TO-CELL TRANSMISSION; APOLIPOPROTEIN-E; HUMAN HEPATOCYTES; CORE PROTEIN; CANDIDATE RECEPTOR; NATURAL-HISTORY;

D O I：

10.3748/wjg.v22.i6.1953

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Hepatitis C virus (HCV) infects over 150 million people worldwide. In most cases, HCV infection becomes chronic causing liver disease ranging from fibrosis to cirrhosis and hepatocellular carcinoma. Viral persistence and pathogenesis are due to the ability of HCV to deregulate specific host processes, mainly lipid metabolism and innate immunity. In particular, HCV exploits the lipoprotein machineries for almost all steps of its life cycle. The aim of this review is to summarize current knowledge concerning the interplay between HCV and lipoprotein metabolism. We discuss the role played by members of lipoproteins in HCV entry, replication and virion production.

引用

页码：1953 / 1965

页数：13

共 50 条

[1] Hepatitis C virus relies on lipoproteins for its life cycle
Germana Grassi
Giorgia Di Caprio
Gian Maria Fimia
Giuseppe Ippolito
Marco Tripodi
Tonino Alonzi
World Journal of Gastroenterology, 2016, 22 (06) : 1953 - 1965
[2] Hepatitis C Virus, Cholesterol and Lipoproteins - Impact for the Viral Life Cycle and Pathogenesis of Liver Disease
Felmlee, Daniel J.
Hafirassou, Mohamed Lamine
Lefevre, Mathieu
Baumert, Thomas F.
Schuster, Catherine
VIRUSES-BASEL, 2013, 5 (05): : 1292 - 1324
[3] Virology and cell biology of the hepatitis C virus life cycle - An update
Dubuisson, Jean
Cosset, Francois-Loic
JOURNAL OF HEPATOLOGY, 2014, 61 : S3 - S13
[4] Hepatitis C Virus Uses Host Lipids to Its Own Advantage
Sidorkiewicz, Malgorzata
METABOLITES, 2021, 11 (05)
[5] Relevance of Rab Proteins for the Life Cycle of Hepatitis C Virus
Elgner, Fabian
Hildt, Eberhard
Bender, Daniela
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2018, 6
[6] Cellular Lipid Droplets and Hepatitis C Virus Life Cycle
Fukasawa, Masayoshi
BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2010, 33 (03) : 355 - 359
[7] Host cell kinases and the hepatitis C virus life cycle
Colpitts, Che C.
Lupberger, Joachim
Doerig, Christian
Baumert, Thomas F.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2015, 1854 (10): : 1657 - 1662
[8] The specific infectivity of hepatitis C virus changes through its life cycle
Keum, Sun Ju
Park, Sung Mi
Park, Ji Hoon
Jung, Jong Ha
Shin, Eun Ji
Jang, Sung Key
VIROLOGY, 2012, 433 (02) : 462 - 470
[9] Impact of lipids and lipoproteins on hepatitis C virus infection and virus neutralization
Vercauteren, Koen
Mesalam, Ahmed Atef
Leroux-Roels, Geert
Meuleman, Philip
WORLD JOURNAL OF GASTROENTEROLOGY, 2014, 20 (43) : 15975 - 15991
[10] Current and future targets of antiviral therapy in the hepatitis C virus life cycle
Eyre, Nicholas S.
Helbig, Karla J.
Beard, Michael R.
FUTURE VIROLOGY, 2014, 9 (11) : 947 - 965

← 1 2 3 4 5 →