Transgenic expression of activated K-RAS in pancreatic acinar cells causes pancreatic damage resembling chronic pancreatitis

被引:0
|
作者
Ji, B.
Song, J.
Logsdon, C. D.
机构
[1] Univ Texas, MD Anderson Canc Ctr, Dept Canc Biol, Houston, TX 77030 USA
[2] Univ Texas, MD Anderson Canc Ctr, Dept GI Med Oncol, Houston, TX 77030 USA
关键词
D O I
10.1097/00006676-200611000-00121
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
引用
收藏
页码:472 / 472
页数:1
相关论文
共 50 条
  • [41] Sensitization of Human Pancreatic Cancer Cells Harboring Mutated K-ras to Apoptosis
    Shen, Ling
    Kim, Sung-Hoon
    Chen, Chang Yan
    PLOS ONE, 2012, 7 (07):
  • [42] Context-Dependent Transformation of Adult Pancreatic Cells by Oncogenic K-Ras
    Friedlander, Sharon Y. Gidekel
    Chu, Gerald C.
    Snyder, Eric L.
    Girnius, Nomeda
    Dibelius, Gregory
    Crowley, Denise
    Vasile, Eliza
    DePinho, Ronald A.
    Jacks, Tyler
    CANCER CELL, 2009, 16 (05) : 379 - 389
  • [43] Metabolomic and transcriptomic profiling of human K-ras oncogene transgenic rats with pancreatic ductal adenocarcinomas
    Yabushita, Setsuko
    Fukamachi, Katsumi
    Tanaka, Hajime
    Fukuda, Takako
    Sumida, Kayo
    Deguchi, Yoshihito
    Mikata, Kazuki
    Nishioka, Kazuhiko
    Kawamura, Satoshi
    Uwagawa, Satoshi
    Suzui, Masumi
    Alexander, David B.
    Tsuda, Hiroyuki
    CARCINOGENESIS, 2013, 34 (06) : 1251 - 1259
  • [44] Long-term follow-up of patients with chronic pancreatitis and K-ras gene mutation detected in pancreatic juice
    Furuya, N
    Kawa, S
    Akamatsu, T
    Furihata, K
    GASTROENTEROLOGY, 1997, 113 (02) : 593 - 598
  • [45] Ectopic expression of metallothionein-III causes pancreatic acinar cell necrosis in transgenic mice
    Quaife, CJ
    Kelly, EJ
    Masters, BA
    Brinster, RL
    Palmiter, RD
    TOXICOLOGY AND APPLIED PHARMACOLOGY, 1998, 148 (01) : 148 - 157
  • [46] Altered MANF Expression in Pancreatic Acinar and Ductal Cells in Chronic Alcoholic Pancreatitis: A Cross-Sectional Study
    Caldwell, Nicholas J.
    Li, Hui
    Bellizzi, Andrew M.
    Luo, Jia
    BIOMEDICINES, 2023, 11 (02)
  • [47] Association of matrilysin mRNA expression with K-ras mutations and progression in pancreatic ductal adenocarcinomas
    Fukushima, H
    Yamamoto, H
    Itoh, F
    Nakamura, H
    Min, YF
    Horiuchi, S
    Iku, S
    Sasaki, S
    Imai, K
    CARCINOGENESIS, 2001, 22 (07) : 1049 - 1052
  • [48] Identification of K-ras 12 Point Mutations Through Colorimetric Analysis in Patients with Pancreatitis and Pancreatic Malignancy
    Ollar, Robert
    Sonpal, Niket
    Duddempudi, Sushil
    Kasmin, Franklin
    Wayne, Micheal
    Cooperman, Avram
    AMERICAN JOURNAL OF GASTROENTEROLOGY, 2009, 104 : S66 - S67
  • [49] A homologous promoterless K-ras cDNA targeting endogenous K-ras expression inhibits human pancreatic cancer cell growth in vitro and in vivo
    Xin-Yu, Ren
    Zhi-Yong, Liang
    Xiao-Hua, Shi
    Tong-Hua, Liu
    CANCER BIOLOGY & THERAPY, 2008, 7 (10) : 1641 - 1647
  • [50] Molecular consequences of silencing mutant K-ras in pancreatic cancer cells:: Justification for K-ras-directed therapy
    Fleming, JB
    Shen, GL
    Holloway, SE
    Davis, M
    Brekken, RA
    MOLECULAR CANCER RESEARCH, 2005, 3 (07) : 413 - 423