Immune System Dysfunction in the Elderly

被引：165
作者：
Fuentes, Eduardo [1 ,2 ]
Fuentes, Manuel [1 ]
Alarcon, Marcelo [1 ]
Palomo, Ivan [1 ]
机构：
[1] Univ Talca, Platelet Res Lab, Dept Clin Biochem & Immunohematol, Fac Hlth Sci,Interdisciplinary Excellence Res Pro, Casilla 747, Talca 3460000, Chile
[2] Univ Talca, Nucleo Cient Multidisciplinario, Casilla 747, Talca 3460000, Chile
来源：
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS | 2017年 / 89卷 / 01期
关键词：
aging; immunosenescence; adaptive immunity; innate immunity; inflammation; NATURAL-KILLER-CELLS; NEUTROPHIL CHEMOTACTIC FACTOR; CD8(+) T-CELLS; DENDRITIC CELLS; REPLICATIVE SENESCENCE; ADAPTIVE IMMUNITY; GENE-EXPRESSION; B-CELLS; DYSREGULATED EXPRESSION; MICROGLIAL ACTIVATION;
D O I：
10.1590/0001-3765201720160487
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Human aging is characterized by both physical and physiological frailty that profoundly affects the immune system. In this context aging is associated with declines in adaptive and innate immunity established as immunosenescence. Immunosenescence is a new concept that reflects the age-associated restructuring changes of innate and adaptive immune functions. Thus elderly individuals usually present chronic low-level inflammation, higher infection rates and chronic diseases. A study of alterations in the immune system during aging could provide a potentially useful biomarker for the evaluation of immune senescence treatment. The immune system is the result of the interplay between innate and adaptive immunity, yet the impact of aging on this function is unclear. In this article the function of the immune system during aging is explored.
引用
收藏
页码：285 / 299
页数：15
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