Injected nanocrystals for targeted drug delivery

被引：142

作者：

Lu, Yi ^{[1
]}

Li, Ye ^{[2
]}

Wu, Wei ^{[1
]}

机构：

[1] Fudan Univ, Sch Pharm, Dept Pharmaceut, Shanghai 201203, Peoples R China

[2] Shaanxi Acad Tradit Chinese Med, Xian 710003, Peoples R China

来源：

ACTA PHARMACEUTICA SINICA B | 2016年 / 6卷 / 02期

关键词：

Nanocrystals; Targeted drug delivery; Biodistribution; Ligand; Stimuli response; Encapsulation; POORLY SOLUBLE DRUGS; PARTICLE ENGINEERING TECHNOLOGY; HYBRID PACLITAXEL NANOCRYSTALS; IN-VIVO EVALUATION; NEVIRAPINE NANOSUSPENSIONS; ANTISOLVENT PRECIPITATION; NUCLEATION KINETICS; ENHANCE DISSOLUTION; TISSUE DISTRIBUTION; INSOLUBLE DRUG;

D O I：

10.1016/j.apsb.2015.11.005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Nanocrystals are pure drug crystals with sizes in the nanometer range. Due to the advantages of high drug loading, platform stability, and ease of scaling-up, nanocrystals have been widely used to deliver poorly water-soluble drugs. Nanocrystals in the blood stream can be recognized and sequestered as exogenous materials by mononuclear phagocytic system (MPS) cells, leading to passive accumulation in MPS-rich organs, such as liver, spleen and lung. Particle size, morphology and surface modification affect the biodistribution of nanocrystals. Ligand conjugation and stimuli-responsive polymers can also be used to target nanocrystals to specific pathogenic sites. In this review, the progress on injected nanocrystals for targeted drug delivery is discussed following a brief introduction to nanocrystal preparation methods, i.e., top-down and bottom-up technologies. (C) 2016 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

引用

页码：106 / 113

页数：8

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