Synthesis of the C1-C11 segment of tedanolide via vinylogous mukaiyama aldol reaction

被引：0

作者：

Hassfeld, J ^{[1
]}

Kalesse, M ^{[1
]}

机构：

[1] Free Univ Berlin, Fachbereich Organ Chem, Inst Chem, D-14195 Berlin, Germany

来源：

SYNLETT | 2002年 / 12期

关键词：

aldol reactions; Mukaiyama; natural products; dihydroxylations; stereoselective synthesis;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The successful construction of complex natural products depends to a large extent on how efficiently key intermediates can be generated. Here we report our efforts towards the first total synthesis of tedanolide (1), employing Evans' aldol methodology in combination with a vinylogous Mukaiyama aldol reaction (VMAR) and Sharpless' asymmetric dihydroxylation. This protocol allows for rapid access to its numerous chiral centers.

引用

页码：2007 / 2010

页数：4

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