Monascus purpureus NTU 568 fermented product improves memory and learning ability in rats with aluminium-induced Alzheimer's disease

被引：16

作者：

Chen, Chien-Li ^{[1
,2
]}

Chang, Kuang-Yao ^{[3
]}

Pan, Tzu-Ming ^{[3
]}

机构：

[1] SunWay Biotech Co Ltd, Dept Res, 139 Xingai Rd, Taipei 11494, Taiwan

[2] SunWay Biotech Co Ltd, Dev Div, 139 Xingai Rd, Taipei 11494, Taiwan

[3] Natl Taiwan Univ, Dept Biochem Sci & Technol, Coll Life Sci, 1,Sec 4,Roosevelt Rd, Taipei 10617, Taiwan

来源：

JOURNAL OF FUNCTIONAL FOODS | 2016年 / 21卷

关键词：

Alzheimer's disease; Monascus purpureus NTU 568; ANKASCIN; 568; plus; Aluminium; Amyloid beta; HIGH-FAT DIET; RED MOLD DIOSCOREA; MONACOLIN-K; OXIDATIVE DAMAGE; INFUSED RAT; IN-VIVO; ANKAFLAVIN; IRON; PEPTIDE; SAFETY;

D O I：

10.1016/j.jff.2015.12.017

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Oxidative stress and neuroinflammation induced by accumulation of amyloid beta (A beta) and phosphorylated tau protein (p-tau) are the main causes of Alzheimer's disease (AD). We examined the effects of Monascus purpureus NTU 568 fermented product (ANKASCIN 568 plus) in the model of Sprague-Dawley rats via oral garage to induce AD pathology which received aluminium chloride on a daily basis. ANKASCIN 568 plus mitigated cognitive impairment in behavioural tests, reduced oxidative stress in the brain, reversed aluminium induced AD brain pathology including accumulation of A beta, p-tau, and amyloid precursor protein; elevated acetylcholinesterase activity, and altered biomarker levels in the cerebrospinal fluid. ANKASCIN 568 plus showed a significant improvement relative to Aricept, an approved drug for AD, in several parameters. Thus, by suppressing free radical generation and activating antioxidant enzymes, ANKASCIN 568 plus can reduce oxidative stress and ameliorate AD pathology, thus protecting rats against aluminium-induced memory and learning deficits. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：167 / 177

页数：11

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