New routes to organofluorine compounds based on ketenes and the radical transfer of xanthates

被引：56

作者：

Zard, Samir Z. ^{[1
]}

机构：

[1] Ecole Polytech, Dept Chim, Organ Synth Lab, F-91128 Palaiseau, France

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2007年 / 5卷 / 02期

关键词：

D O I：

10.1039/b615592h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New routes to organofluorine derivatives based mostly on the powerful xanthate radical transfer technology are described. A special emphasis is placed on the synthesis of trifluoromethyl- substituted structures, including trifluromethyl ketones and fluorinated aromatic and heteroaromatic substances of interest to the pharmaceutical and agrochemical industries.

引用

页码：205 / 213

页数：9

共 61 条

[1] α-functionalised ketones as promoters of alkene epoxidation by Oxone® [J].

Armstrong, A ;

Hayter, BR .

TETRAHEDRON, 1999, 55 (36) :11119-11126

[2]

Aubert C, 2000, RAPID COMMUN MASS SP, V14, P960

[3] A flexible strategy for the divergent modification of pleuromutilin [J].

Bacqué, E ;

Pautrat, F ;

Zard, SZ .

CHEMICAL COMMUNICATIONS, 2002, (20) :2312-2313

[4]

Barbier F, 2002, SYNLETT, P811

[5] α-Scission of sulfonyl radicals:: a versatile process for organic synthesis [J].

Bertrand, F ;

Le Guyader, F ;

Liguori, L ;

Ouvry, G ;

Quiclet-Sire, B ;

Seguin, S ;

Zard, SZ .

COMPTES RENDUS DE L ACADEMIE DES SCIENCES SERIE II FASCICULE C-CHIMIE, 2001, 4 (07) :547-555

[6] A xanthate transfer radical process for the introduction of the trifluoromethyl group [J].

Bertrand, F ;

Pevere, V ;

Quiclet-Sire, B ;

Zard, SZ .

ORGANIC LETTERS, 2001, 3 (07) :1069-1071

[7]

Bertrand F, 1999, ANGEW CHEM INT EDIT, V38, P1943, DOI 10.1002/(SICI)1521-3773(19990712)38:13/14<1943::AID-ANIE1943>3.0.CO

[8]

2-R

[9] Access to 4-substituted 3,4-dihydroquinolin-2(1H)-ones by an unusual radical cyclisation of a secondary amide [J].

Binot, G ;

Zard, SZ .

TETRAHEDRON LETTERS, 2005, 46 (44) :7503-7506

[10] Trifluoromethyl ketone inhibitors of fatty acid amide hydrolase: A probe of structural and conformational features contributing to inhibition [J].

Boger, DL ;

Sato, H ;

Lerner, AE ;

Austin, BJ ;

Patterson, JE ;

Patricelli, MP ;

Cravatt, BF .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1999, 9 (02) :265-270

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