Long-term treatment with haloperidol affects neuropeptide S and NPSR mRNA levels in the rat brain

被引:9
作者
Palasz, Artur [1 ]
Rojczyk, Ewa [1 ]
Golyszny, Milosz [2 ]
Filipczyk, Lukasz [1 ]
Worthington, John J. [3 ]
Wiaderkiewicz, Ryszard [1 ]
机构
[1] Med Univ Silesia, Sch Med Katowice, Dept Histol, 18 Med St, PL-40752 Katowice, Poland
[2] Med Univ Silesia, Student Sci Soc, 18 Med St, PL-40752 Katowice, Poland
[3] Univ Manchester, Manchester Immunol Grp, Manchester, Lancs, England
来源
ACTA NEUROPSYCHIATRICA | 2016年 / 28卷 / 02期
关键词
brainstem; haloperidol; neuroleptics; neuropeptide s; NPSR; A10 DOPAMINE NEURONS; ANTIPSYCHOTIC-DRUGS; RECEPTOR GENE; MOUSE-BRAIN; ANXIETY; EXPRESSION; OLANZAPINE; CLOZAPINE; SCHIZOPHRENIA; STRESS;
D O I
10.1017/neu.2015.56
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Objective The brainstem-derived neuropeptide S (NPS) has a multidirectional regulatory activity, especially as a potent anxiolytic factor. Accumulating data suggests that neuroleptics affect peptidergic signalling in various brain structures. However, there is no information regarding the influence of haloperidol on NPS and NPS receptor (NPSR) expression. Methods We assessed NPS and NPSR mRNA levels in brains of rats treated with haloperidol using quantitative real-time polymerase chain reaction. Results Chronic haloperidol treatment (4 weeks) led to a striking upregulation of NPS and NPSR expression in the rat brainstem. Conversely, the NPSR mRNA expression was decreased in the hippocampus and striatum. Conclusions This stark increase of NPS in response to haloperidol treatment supports the hypothesis that this neuropeptide is involved in the dopamine-dependent anxiolytic actions of neuroleptics and possibly also in the pathophysiology of mental disorders. Furthermore, our findings underline the complex nature of potential interactions between dopamine receptors and brain peptidergic pathways, which has potential clinical applications.
引用
收藏
页码:110 / 116
页数:7
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