Epilepsy add-on therapy with pregabalin: Treatment follow-up in 103 patients

被引：5

作者：

Bauer, J. ^{[1
]}

Ruocco, A. ^{[1
]}

机构：

[1] Univ Klinikum Bonn, Klin Epileptol, D-53105 Bonn, Germany

来源：

AKTUELLE NEUROLOGIE | 2006年 / 33卷 / 08期

关键词：

D O I：

10.1055/s-2006-940083

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Pregabalin (PGB) is a new antiepileptic drug that is not metabolized by the liver. Treatment with PGB is authorized for patients with intractable epilepsy with focal and/or secondarily generalized seizures. We have evaluated the course of an add-on treatment with PGB in 103 patients (mean age: 37.7 years). 35 patients discontinued the drug within the first 4 months of therapy. After 12 months 33 patients still remained on PGB (another 4 were lost during follow-up). 10 of these patients had a therapeutic benefit with a decrease of seizure frequency (8) or complete seizure control (2).

引用

页码：439 / 441

页数：3

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[31] Sulthiame add-on therapy for epilepsy [J].

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[34] Pregabalin as add-on therapy induces REM sleep enhancement in partial epilepsy: a polysomnographic study [J].

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[38] Topiramate as add-on therapy in non-respondent alcohol dependant patients:: a 12 month follow-up study [J].

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[39] Efficacy of levetiracetam as an add-on therapy in patients with startle epilepsy [J].

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