Reduced intracellular accumulation of azole antifungal results in resistance in Candida albicans isolate NCPF 3363

被引：11
|
作者：
Lamb, DC
Kelly, DE
Manning, NJ
Kelly, SL
机构：
[1] UNIV SHEFFIELD,KREBS INST BIOMOLEC RES,DEPT MOL BIOL & BIOTECHNOL,SHEFFIELD S10 2UH,S YORKSHIRE,ENGLAND
[2] SHEFFIELD CHILDRENS HOSP,NEONATAL SCREENING LAB,SHEFFIELD S10 2UH,S YORKSHIRE,ENGLAND
来源：
FEMS MICROBIOLOGY LETTERS | 1997年 / 147卷 / 02期
关键词：
Candida albicans; azole antifungal; resistance; P450;
D O I：
10.1111/j.1574-6968.1997.tb10240.x
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Candida albicans strain NCPF 3363 was isolated from a British patient with chronic mucocutaneous candidiasis (CMC) and confirmed to be resistant to azole antifungal compounds. In this study we investigate the molecular basis of resistance and show that azole tolerance in NCPF 3363 was associated with reduced intracellular accumulation of drug and not reduced affinity for the target site, as previously indicated. Relative impermeability or the presence of transporters related to those responsible for multidrug resistance are implicated in the mechanism of resistance.
引用
收藏
页码：189 / 193
页数：5
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