Role of Resveratrol in Modulating microRNAs in Human Diseases: From Cancer to Inflammatory Disorder

被引：38

作者：

Amiri, Atefeh ^{[1
]}

Mahjoubin-Tehran, Maryam ^{[1
,2
]}

Asemi, Zatollah ^{[3
]}

Shafiee, Alimohammad ^{[4
]}

Hajighadimi, Sarah ^{[4
]}

Moradizarmehri, Sanaz ^{[4
]}

Mirzaei, Hamid Reza ^{[5
]}

Mirzaei, Hamed ^{[3
]}

机构：

[1] Mashhad Univ Med Sci, Sch Med, Dept Med Biotechnol, Mashhad, Razavi Khorasan, Iran

[2] Mashhad Univ Med Sci, Student Res Comm, Mashhad, Razavi Khorasan, Iran

[3] Kashan Univ Med Sci, Inst Basic Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran

[4] Toronto Gen Hosp, Div Gen Internal Med, Toronto, ON, Canada

[5] Univ Tehran Med Sci, Sch Med, Dept Med Immunol, Tehran, Iran

来源：

CURRENT MEDICINAL CHEMISTRY | 2021年 / 28卷 / 02期

关键词：

Resveratrol; microRNA; cancer; therapy; non-coding RNAs; non-cancerous diseases; ACUTE LUNG INJURY; UP-REGULATION; COLORECTAL-CANCER; INDUCED APOPTOSIS; MIR-21; REGULATION; CELL APOPTOSIS; EXPRESSION; IMPROVES; QUERCETIN; MELANOMA;

D O I：

10.2174/0929867326666191212102407

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cancer and inflammatory disorders are two important public health issues worldwide with significant socio-economic impacts. Despite several efforts, the current therapeutic platforms are associated with severe limitations. Therefore, developing new therapeutic strategies for the treatment of these diseases is a top priority. Besides current therapies, the utilization of natural compounds has emerged as a new horizon for the treatment of cancer and inflammatory disorders as well. Such natural compounds could be used either alone or in combination with the standard cancer therapeutic modalities such as chemotherapy, radiotherapy, and immunotherapy. Resveratrol is a polyphenolic compound that is found in grapes as well as other foods. It has been found that this medicinal agent displays a wide pharmacological spectrum, including anti-cancer, anti-inflammatory, anti-microbial, and antioxidant activities. Recently, clinical and pre-clinical studies have highlighted the anti-cancer and anti-inflammatory effects of resveratrol. Increasing evidence revealed that resveratrol exerts its therapeutic effects by targeting various cellular and molecular mechanisms. Among cellular and molecular targets that are modulated by resveratrol, microRNAs (miRNAs) have appeared as key targets. MiRNAs are short non-coding RNAs that act as epigenetic regulators. These molecules are involved in many processes that are involved in the initiation and progression of cancer and inflammatory disorders. Herein, we summarized various miRNAs that are directly/indirectly influenced by resveratrol in cancer and inflammatory disorders.

引用

页码：360 / 376

页数：17