Spirobisnaphthalenes effectively inhibit carbonic anhydrase

被引：27

作者：

Gocer, Hulya ^{[1
]}

Aslan, Abdulselam ^{[2
]}

Gulcin, Ilhami ^{[3
,4
]}

Supuran, Claudiu T. ^{[5
,6
]}

机构：

[1] Ibrahim Cecen Univ Agri, Cent Res Lab, TR-04100 Agri, Turkey

[2] Ibrahim Cecen Univ Agri, Sch Hlth, Agri, Turkey

[3] Ataturk Univ, Fac Sci, Dept Chem, TR-25240 Erzurum, Turkey

[4] King Saud Univ, Coll Sci, Dept Zool, Riyadh 11451, Saudi Arabia

[5] Univ Florence, Dipartimento Chim Ugo Schiff, Florence, Italy

[6] Univ Florence, Neurofarba Dept, Sect Pharmaceut & Nutriceut Sci, Florence, Italy

来源：

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2016年 / 31卷 / 03期

关键词：

Carbonic anhydrase; enzyme inhibition; enzyme purification; spirobisnaphthalenes; TROUT ONCORHYNCHUS-MYKISS; ERYTHROCYTES IN-VITRO; THERAPEUTIC APPLICATIONS; CLADOSPIRONE BISEPOXIDE; ABSOLUTE-CONFIGURATION; FUNGAL METABOLITES; ISOENZYMES I; DERIVATIVES; DEOXYPREUSSOMERINS; MELATONIN;

D O I：

10.3109/14756366.2015.1043298

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This study explores the correlation between human carbonic anhydrase (CA, EC 4.2.1.1) isoforms I and II (hCA I, II) and the inhibitory features of some spirobisnaphthalene derivatives. A group of spirobisnaphthalenes was synthesized and their hCA I and II inhibitory effects was investigated. The K-i values were similar for both CA isoenzymes, the compounds showing good inhibitory activity. K-i values ranged between 1.60 and 460.42 mu M for hCA I and between 0.39 and 419.42 mu M for hCA II, respectively. The spirobisnaphthalenes derivatives might be useful for designing CA inhibitors belonging to novel chemotypes compared to the highly investigated sulfonamides, sulfamates or coumarins.

引用

页码：503 / 507

页数：5

共 78 条

[1] Synthesis and Carbonic Anhydrase Inhibitory Effects of Novel Sulfamides Derived from 1-Aminoindanes and Anilines [J].

Akbaba, Yusuf ;

Bastem, Enes ;

Topal, Fevzi ;

Gulcin, Ilhami ;

Maras, Ahmet ;

Goksu, Suleyman .

ARCHIV DER PHARMAZIE, 2014, 347 (12) :950-957

[2] Carbonic anhydrase inhibitory properties of novel sulfonamide derivatives of aminoindanes and aminotetralins [J].

Akbaba, Yusuf ;

Akincioglu, Akin ;

Gocer, Hulya ;

Goksu, Suleyman ;

Gulcin, Ilhami ;

Supuran, Claudiu T. .

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2014, 29 (01) :35-42

[3] Novel Sulphamides and Sulphonamides Incorporating the Tetralin Scaffold as Carbonic Anhydrase and Acetylcholine Esterase Inhibitors [J].

Akincioglu, Akin ;

Topal, Meryem ;

Guelcin, Ilhami ;

Goeksu, Sueleyman .

ARCHIV DER PHARMAZIE, 2014, 347 (01) :68-76

[4] Novel sulfamides as potential carbonic anhydrase isoenzymes inhibitors [J].

Akincioglu, Akin ;

Akbaba, Yusuf ;

Gocer, Hulya ;

Goksu, Suleyman ;

Gulcin, Ilhami ;

Supuran, Claudiu T. .

BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 21 (06) :1379-1385

[5] Synthesis and carbonic anhydrase inhibitory properties of sulfamides structurally related to dopamine [J].

Aksu, Kadir ;

Nar, Meryem ;

Tanc, Muhammet ;

Vullo, Daniela ;

Gulcin, Ilhami ;

Goksu, Suleyman ;

Tumer, Ferhan ;

Supuran, Claudiu T. .

BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 21 (11) :2925-2931

[6]

Alterio V, 2012, J AM CHEM SOC, V112, P4421

[7]

[Anonymous], 2007, EUR J ORG CHEM

[8] Capsaicin: A Potent Inhibitor of Carbonic Anhydrase Isoenzymes [J].

Arabaci, Betul ;

Gulcin, Ilhami ;

Alwasel, Saleh .

MOLECULES, 2014, 19 (07) :10103-10114

[9] Effect of vitamin E on carbonic anhydrase enzyme activity in rainbow trout (Oncorhynchus mykiss) erythrocytes in vitro and in vivo [J].

Aras-Hisar, S ;

Hisar, O ;

Beydemir, S ;

Gülcin, I ;

Yanik, T .

ACTA VETERINARIA HUNGARICA, 2004, 52 (04) :413-422

[10] Synthesis of Biologically Active Nonnatural Palmarumycin Derivatives [J].

Aslan, Abdulselam ;

Altun, Sultan ;

Ahmed, Ishtiaq ;

Floerke, Ulrich ;

Schulz, Barbara ;

Krohn, Karsten .

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2011, 2011 (06) :1176-1188

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