Celiac disease: pathogenesis of a model immunogenetic disease

被引:240
作者
Kagnoff, Martin F.
机构
[1] Univ Calif San Diego, Wm K Warren Med Res Ctr Celiac Dis, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Lab Mucosal Immunol, Dept Med, La Jolla, CA 92093 USA
[3] Univ Calif San Diego, Lab Mucosal Immunol, Dept Pediat, La Jolla, CA 92093 USA
关键词
D O I
10.1172/JCI30253
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Celiac disease is characterized by small-intestinal mucosal injury and nutrient malabsorption in genetically susceptible individuals in response to the dietary ingestion of wheat gluten and similar proteins in barley and rye. Disease pathogenesis involves interactions among environmental, genetic, and immunological factors. Although celiac disease is predicted by screening studies to affect approximately 1% of the population of the United States and is seen both in children and in adults, 10%/15% or fewer of these individuals have been diagnosed and treated. This article focuses on the role of adaptive and innate immune mechanisms in the pathogenesis of celiac disease and how current concepts of immunopathogenesis might provide alternative approaches for treating celiac disease.
引用
收藏
页码:41 / 49
页数:9
相关论文
共 97 条
  • [1] In vivo antigen challenge in celiac disease identifies a single transglutaminase-modified peptide as the dominant A-gliadin T-cell epitope
    Anderson, RP
    Degano, P
    Godkin, AJ
    Jewell, DP
    Hill, AVS
    [J]. NATURE MEDICINE, 2000, 6 (03) : 337 - 342
  • [2] T cells in peripheral blood after gluten challenge in coeliac disease
    Anderson, RP
    van Heel, DA
    Tye-Din, JA
    Barnardo, M
    Salio, M
    Jewell, DP
    Hill, AVS
    [J]. GUT, 2005, 54 (09) : 1217 - 1223
  • [3] The molecular basis for oat intolerance in patients with Celiac disease
    Arentz-Hansen, H
    Fleckenstein, B
    Molberg, O
    Scott, H
    Koning, F
    Jung, G
    Roepstorff, P
    Lundin, KEA
    Sollid, LM
    [J]. PLOS MEDICINE, 2004, 1 (01) : 84 - 92
  • [4] The intestinal T cell response to α-gliadin in adult celiac disease is focused on a single deamidated glutamine targeted by tissue transglutaminase
    Arentz-Hansen, H
    Körner, R
    Molberg, O
    Quarsten, H
    Vader, W
    Kooy, YMC
    Lundin, KEA
    Koning, F
    Roepstorff, P
    Sollid, LM
    McAdam, SN
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 191 (04) : 603 - 612
  • [5] Celiac lesion T cells recognize epitopes that cluster in regions of gliadins rich in proline residues
    Arentz-Hansen, H
    McAdam, SN
    Molberg, O
    Fleckenstein, B
    Lundin, KEA
    Jorgensen, TJD
    Jung, G
    Roepstorff, P
    Sollid, LM
    [J]. GASTROENTEROLOGY, 2002, 123 (03) : 803 - 809
  • [6] Celiac disease during interferon treatment
    Bardella, MT
    Marino, R
    Meroni, PL
    [J]. ANNALS OF INTERNAL MEDICINE, 1999, 131 (02) : 157 - 158
  • [7] Main chain hydrogen bond interactions in the binding of proline-rich gluten peptides to the Celiac disease-associated HLA-DQ2 molecule
    Bergseng, E
    Xia, J
    Kim, CY
    Khosla, C
    Sollid, LM
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (23) : 21791 - 21796
  • [8] Onset of coeliac disease during treatment with interferon for chronic hepatitis C
    Cammarota, G
    Cuoco, L
    Cianci, R
    Pandolfi, F
    Gasbarrini, G
    [J]. LANCET, 2000, 356 (9240) : 1494 - 1495
  • [9] Association of celiac disease and intestinal lymphomas and other cancers
    Catassi, C
    Bearzi, I
    Holmes, GKT
    [J]. GASTROENTEROLOGY, 2005, 128 (04) : S79 - S86
  • [10] Abnormal intestinal intraepithelial lymphocytes in refractory sprue
    Cellier, C
    Patey, N
    Mauvieux, L
    Jabri, B
    Delabesse, E
    Cervoni, JP
    Burtin, ML
    Guy-Grand, D
    Bouhnik, Y
    Modigliani, R
    Barbier, JP
    Macintyre, E
    Brousse, N
    Cerf-Bensussan, N
    [J]. GASTROENTEROLOGY, 1998, 114 (03) : 471 - 481