Serotonin transporter binding increases in caudate-putamen and nucleus accumbens after neonatal 6-hydroxydopamine lesions in rats: implications for motor hyperactivity

被引:27
作者
Zhang, KH
Davids, E
Tarazi, FI
Baldessarini, RJ
机构
[1] Massachusetts Gen Hosp, Mailman Res Ctr, McLean Div, Belmont, MA 02478 USA
[2] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA
[3] Harvard Univ, Sch Med, Program Neurosci, Boston, MA 02115 USA
来源
DEVELOPMENTAL BRAIN RESEARCH | 2002年 / 137卷 / 02期
关键词
motor hyperactivity; 6-hydroxydopamine; 5-hydroxytryptamine (5-HT) transporter; caudate-putamen; nucleus accumbens; development;
D O I
10.1016/S0165-3806(02)00436-4
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
We examined serotonin (5-HT) transporters in rat forebrain using quantitative autoradiography at three distinct developmental stages after neonatal 6-hydroxydopamine lesions. The lesions substantially increased 5-HT transporter binding in both caudate-putamen and nucleus accumbens, but not cerebral cortex. The effects reached maximal levels as early as postnatal day (PD) 24, and were sustained until early adulthood. Behavioral analyses indicated that neonatal lesions resulted in motor hyperactivity on PD 24, but not on PD 36 or 59. These findings suggest that excess 5-HT transporters reflect serotonin hyperinnervation reported to occur in lesioned rats, and may modulate motor hyperactivity. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:135 / 138
页数:4
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