Palladium-Catalyzed Aromatic C-H Halogenation with Hydrogen Halides by Means of Electrochemical Oxidation

被引：293

作者：

Kakiuchi, Fumitoshi ^{[1
]}

Kochi, Takuya ^{[1
]}

Mutsutani, Hitoshi ^{[1
]}

Kobayashi, Noboru ^{[1
]}

Urano, Seiya ^{[1
]}

Sato, Mitsuo ^{[1
]}

Nishiyama, Shigeru ^{[1
]}

Tanabe, Takamasa ^{[1
]}

机构：

[1] Keio Univ, Dept Chem, Fac Sci & Technol, Kohoku Ku, Kanagawa 2238522, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 32期

关键词：

BOND FORMATION; FUNCTIONALIZATION; GENERATION; CHEMISTRY;

D O I：

10.1021/ja9049228

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new strategy for catalytic functionalization of C-H bonds by means of electrochemical oxidation is described. Combination of palladium-catalyzed aromatic C-H bond cleavage and halogenation with electrochemically generated halonium ions enables highly efficient, selective halogenations of aromatic compounds in a green-sustainable manner. The required reagents for this reaction are an arene and an aqueous hydrogen halide as substrates, a palladium salt as a catalyst, and an organic solvent. No further additives such as electrolytes, oxidants, or ligands are necessary to achieve effective catalytic activity. Several remarkable advantages of the use of the electrochemical method are also described.

引用

页码：11310 / +

页数：4

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