The Rules and Functions of Nucleocytoplasmic Shuttling Proteins

被引：57

作者：

Fu, Xuekun ^{[1
,2
,3
]}

Liang, Chao ^{[3
,4
,5
,6
]}

Li, Fangfei ^{[3
,4
,5
,6
]}

Wang, Luyao ^{[3
,4
,5
,6
]}

Wu, Xiaoqiu ^{[3
,4
,5
,6
]}

Lu, Aiping ^{[3
,4
,5
,6
]}

Xiao, Guozhi ^{[1
,2
,7
]}

Zhang, Ge ^{[3
,4
,5
,6
]}

机构：

[1] Southern Univ Sci & Technol, Dept Biol, Shenzhen 518055, Peoples R China

[2] Southern Univ Sci & Technol, Guangdong Prov Key Lab Cell Microenvironm & Dis R, Shenzhen 518055, Peoples R China

[3] Hong Kong Baptist Univ, Law Sau Fai Inst Adv Translat Med Bone & Joint Di, Sch Chinese Med, Hong Kong, Hong Kong, Peoples R China

[4] Hong Kong Baptist Univ, Inst Integrated Bioinfomed & Translat Sci, Sch Chinese Med, Hong Kong, Hong Kong, Peoples R China

[5] Hong Kong Baptist Univ, Inst Precis Med & Innovat Drug Discovery, Sch Chinese Med, Hong Kong, Hong Kong, Peoples R China

[6] HKBU Inst Res & Continuing Educ, Shenzhen Lab Combinatorial Cpds & Targeted Drug D, Shenzhen 518057, Peoples R China

[7] Rush Univ, Dept Orthoped Surg, Med Ctr, Chicago, IL 60612 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2018年 / 19卷 / 05期

基金：

中国国家自然科学基金;

关键词：

nucleocytoplasmic transport; shuttling protein; cancer; neurodegenerative diseases; leukemia; osteoporosis; fanconi anemia; NUCLEAR-PORE COMPLEX; ACUTE MYELOGENOUS LEUKEMIA; CAP-BINDING PROTEIN; NF-KAPPA-B; NEURODEGENERATIVE DISEASES; LOCALIZATION SIGNAL; MOLECULAR ARCHITECTURE; TRANSPORT RECEPTOR; KARYOPHERIN ALPHA; NORMAL KARYOTYPE;

D O I：

10.3390/ijms19051445

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Biological macromolecules are the basis of life activities. There is a separation of spatial dimension between DNA replication and RNA biogenesis, and protein synthesis, which is an interesting phenomenon. The former occurs in the cell nucleus, while the latter in the cytoplasm. The separation requires protein to transport across the nuclear envelope to realize a variety of biological functions. Nucleocytoplasmic transport of protein including import to the nucleus and export to the cytoplasm is a complicated process that requires involvement and interaction of many proteins. In recent years, many studies have found that proteins constantly shuttle between the cytoplasm and the nucleus. These shuttling proteins play a crucial role as transport carriers and signal transduction regulators within cells. In this review, we describe the mechanism of nucleocytoplasmic transport of shuttling proteins and summarize some important diseases related shuttling proteins.

引用

页数：17

共 110 条

[1] The molecular architecture of the nuclear pore complex [J].