The Role of the Adipokine Leptin in Immune Cell Function in Health and Disease

被引：117
作者：
Kiernan, Kaitlin [1 ]
MacIver, Nancie J. [1 ,2 ,3 ]
机构：
[1] Duke Univ, Sch Med, Dept Immunol, Durham, NC 27707 USA
[2] Duke Univ, Sch Med, Dept Pediat, Durham, NC 27707 USA
[3] Duke Univ, Sch Med, Dept Pharmacol & Canc Biol, Durham, NC 27707 USA
来源：
FRONTIERS IN IMMUNOLOGY | 2021年 / 11卷
基金：
美国国家卫生研究院;
关键词：
leptin; obesity; inflammation; adaptive immunity; adipose tissue; DENDRITIC CELLS; DEFICIENT MICE; RECEPTOR; OBESITY; HOMEOSTASIS; ACTIVATION; EXPRESSION; INDUCTION;
D O I：
10.3389/fimmu.2020.622468
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Leptin is a critical mediator of the immune response to changes in overall nutrition. Leptin is produced by adipocytes in proportion to adipose tissue mass and is therefore increased in obesity. Despite having a well-described role in regulating systemic metabolism and appetite, leptin displays pleiotropic actions, and it is now clear that leptin has a key role in influencing immune cell function. Indeed, many immune cells have been shown to respond to leptin directly via the leptin receptor, resulting in a largely pro-inflammatory phenotype. Understanding the role of adipose-tissue derived mediators in inflammation is critical to determining the pathophysiology of multiple obesity-associated diseases, such as type 2 diabetes, autoimmune disease, and infection. This review, therefore, focuses on the latest data regarding the role of leptin in modulating inflammation.
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页数：11
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