The tyrosine kinase inhibitor methyl 2,5-dihydroxycinnimate disrupts changes in the actin cytoskeleton required for neurite formation

被引：6

作者：

Leventhal, PS ^{[1
]}

Feldman, EL ^{[1
]}

机构：

[1] UNIV MICHIGAN,DEPT NEUROL,ANN ARBOR,MI 48109

来源：

MOLECULAR BRAIN RESEARCH | 1996年 / 43卷 / 1-2期

关键词：

tyrosine phosphorylation; laminin; neurite outgrowth; actin; focal adhesion kinase; paxillin; cytoskeleton;

D O I：

10.1016/S0169-328X(96)00221-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In the current studies, we investigated the relationship between tyrosine phosphorylation and neurite formation. In SH-SY5Y neuroblastoma cells, the tyrosine kinase inhibitor methyl 2,5-dihydroxycinnimate blocked neurite formation on laminin. This corresponded with inhibition of paxillin and focal adhesion kinase tyrosine phosphorylation as well as a disruption of actin filament organization and actin polymerization. This suggests that tyrosine phosphorylation helps direct changes in the actin cytoskeleton required for neurite formation.

引用

页码：338 / 340

页数：3

共 17 条

[1]

BIXBY JL, 1995, J NEUROSCI, V16, P1470

[2] ROLE OF TYROSINE PHOSPHORYLATION IN MATRIX-INDUCED NEURITE OUTGROWTH IN HUMAN NEUROBLASTOMA-CELLS [J].