Isolation, Structural Elucidation, Optical Resolution, and Antineuroinflammatory Activity of Phenanthrene and 9,10-Dihydrophenanthrene Derivatives from Bletilla striata

被引:37
|
作者
Zhou, Di [1 ,3 ]
Chen, Gang [1 ]
Ma, Yue-Ping [1 ]
Wang, Cun-Gang [1 ]
Lin, Bin [2 ]
Yang, Yan-Qiu [4 ]
Li, Wei [1 ,3 ]
Koike, Kazuo [3 ]
Hou, Yue [4 ]
Li, Ning [1 ,5 ]
机构
[1] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang 110016, Liaoning, Peoples R China
[2] Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, Shenyang 110016, Liaoning, Peoples R China
[3] Toho Univ, Fac Pharmaceut Sci, Miyama 2-2-1, Funabashi, Chiba 2748510, Japan
[4] Northeastern Univ, Coll Life & Hlth Sci, Shenyang 110004, Liaoning, Peoples R China
[5] Guangxi Normal Univ, State Key Lab Chem & Mol Engn Med Resources, Guilin 541004, Peoples R China
来源
JOURNAL OF NATURAL PRODUCTS | 2019年 / 82卷 / 08期
基金
中国国家自然科学基金;
关键词
CONSTITUENTS; GLUCOSIDES; DIHYDROPHENANTHRENES; BIBENZYLS; TUBERS;
D O I
10.1021/acs.jnatprod.9b00291
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
A phytochemical investigation of the aqueous EtOH extract of Bletilla striata tubers afforded 34 phenanthrene and 9,10-dihydrophenanthrene derivatives, including four new compounds, 1-4. These compounds were identified using physicochemical analyses and various spectroscopic methods. Twelve of these compounds were resolved into their enantiomers, and the absolute configurations were determined by comparison of experimental and calculated ECD spectra. The antineuroinflammatory activities were evaluated by measuring the inhibition of nitric oxide production in lipopolysaccharide-stimulated BV-2 microglial cells. Compounds 7, 32, and 33 displayed inhibitory activities, with IC50 values of 1.9, 5.0, and 1.0 mu M, respectively, suggesting that they should be subjected to development as potential inhibitors of neuroinflammation.
引用
收藏
页码:2238 / 2245
页数:8
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